Phenolic compounds obtained from the fruit of Crataegus pinnatifida
with neuroprotective activities

多酚 ›› 2019, Vol. 1 ›› Issue (1): 70-75.

• • 上一篇

Phenolic compounds obtained from the fruit of Crataegus pinnatifida with neuroprotective activities

Rui Guo, Fengying Han, Tianming Lv, Xiaoxiao Huang, Shaojiang Song *

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

出版日期:2019-04-16 发布日期:2019-10-28

Phenolic compounds obtained from the fruit of Crataegus pinnatifida with neuroprotective activities

Rui Guo, Fengying Han, Tianming Lv, Xiaoxiao Huang, Shaojiang Song *

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

Online:2019-04-16 Published:2019-10-28
Contact: Shaojiang Song (songsj99@163.com)

摘要/Abstract

摘要： Ten phenolic compounds (1a/1b, 2–9) including a pair of enantiomers (1a/1b), along with eight analogues (2–9) were isolated from the fruit of Crataegus pinnatifida. Enantiomers 1a/1b were separated successfully by chiral chromatographic column. Their structures were established by comprehensive spectroscopic analyses, and the absolute configurations of enantiomers were determined by comparison between the experimental and calculated electronic circular dichroism (ECD) spectra. In addition, all isolates were investigated for their neuroprotective effects against H2O2 – induced oxidative stress in human neuroblastoma SH-SY5Y cells. It was found that enantiomers 1a and 1b displayed significant neuroprotective activities but no enantioselectivity. In addition, compounds 3–6 showed obvious neuroprotective effects at different concentrations, while compound 8 exhibited potential neuroprotective effect at higher concentration (50 μmol/L).

关键词: Crataegus pinnatifida, phenolic compounds, enantiomers, neuroprotective activities, SH-SY5Y

Abstract: Ten phenolic compounds (1a/1b, 2–9) including a pair of enantiomers (1a/1b), along with eight analogues (2–9) were isolated from the fruit of Crataegus pinnatifida. Enantiomers 1a/1b were separated successfully by chiral chromatographic column. Their structures were established by comprehensive spectroscopic analyses, and the absolute configurations of enantiomers were determined by comparison between the experimental and calculated electronic circular dichroism (ECD) spectra. In addition, all isolates were investigated for their neuroprotective effects against H2O2 – induced oxidative stress in human neuroblastoma SH-SY5Y cells. It was found that enantiomers 1a and 1b displayed significant neuroprotective activities but no enantioselectivity. In addition, compounds 3–6 showed obvious neuroprotective effects at different concentrations, while compound 8 exhibited potential neuroprotective effect at higher concentration (50 μmol/L).

Key words: Crataegus pinnatifida, phenolic compounds, enantiomers, neuroprotective activities, SH-SY5Y

Rui Guo, Fengying Han, Tianming Lv, Xiaoxiao Huang, Shaojiang Song. Phenolic compounds obtained from the fruit of Crataegus pinnatifida with neuroprotective activities[J]. 多酚, 2019, 1(1): 70-75.

Rui Guo, Fengying Han, Tianming Lv, Xiaoxiao Huang, Shaojiang Song. Phenolic compounds obtained from the fruit of Crataegus pinnatifida with neuroprotective activities[J]. Journal of Polyphenols, 2019, 1(1): 70-75.

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Phenolic compounds obtained from the fruit of Crataegus pinnatifida with neuroprotective activities

Phenolic compounds obtained from the fruit of Crataegus pinnatifida with neuroprotective activities

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