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    1. Licorice and its main components on the treatment of diabetes and its complications: A review of in vivo and in vitro studies
    Lina Cheng, Shijie Cao, Ming Qu, Ning Kang
    亚洲传统医药    2019, 14 (6): 280-294.  
    摘要70)      PDF(pc) (964KB)(40)    收藏
    Licorice is one of the oldest herbal medicines for its various ethno pharmacological uses. In both Asian and European countries, it has been recorded for treatment of inflammatory diseases. A large number of ingredients have been isolated from licorice, including triterpene saponins and flavonoids, which are normally being considered to be the main biologically active components. In the last decade, licorice has been proved exert anti-diabetic effect in various in vivo and in vitro models of diabetes mellitus. Furthermore, licorice can also antagonize all sorts of diabetes complications, including diabetic nephropathy, atherosclerosis, diabetic retinopathy and neuropathy. Except anti-inflammation, licorice and its active components show anti-diabetic effects by improving insulin resistance and increasing insulin secretion, regulating lipid metabolism, and anti-oxidation. The useful effects of licorice and its active components are due to regulating different pathways and proteins, including NF-κB, AMPK, insulin signaling pathway, MAPK, etc. In this review, we provide an overview of the beneficial effects and related molecular mechanism of licorice and its effective components on improving diabetes and its complications.
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    2. Research review on the main chemical constituents and pharmacological properties of the leaves of Isatis indigotica Fortune
    Wei Hong, Yufei Xi, Weiyu Zhou, Xiaoxiao Huang, Shaojiang Song
    亚洲传统医药    2019, 14 (5): 227-236.  
    摘要60)      PDF(pc) (1236KB)(68)    收藏
    Isatis indigotica Fortune, belonging to Isatis genus of Cruciferae family, is widely used as a common Chinese herbal medicine in folk. As a traditional medicinal agent, a wide spectrum of chemical constituents have been isolated from the leaves, including alkaloids, flavonoids, flavonoid glycosides, organic acids and glycosides. The research shows that the leaves had multiple activities and good development prospect, which has attracted a wide range of attention. Hence, this article is presented as a review concentrating on chemical constituents and pharmacological activities of the leaves of I. indigotica Fort., aiming at supporting practical and useful information for the further research and development of this plant.
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    3. The progress and related pharmacological mechanism of hyperlipidemia treatment
    Zhaohui Ren, Jianxiu Zhai, Na Han, Zhihui Liu, Jun Yin
    亚洲传统医药    2019, 14 (6): 268-279.  
    摘要58)      PDF(pc) (619KB)(45)    收藏
    Hyperlipidemia (HLP) is a long-known risk factor for a series of cardiovascular and cerebrovascular diseases, such as atherosclerosis, coronary heart disease, hypertension and so on. With its increasing incidence, the prevention and treatment of HLP has also become an important research topic around the world. Traditional Chinese medicine (TCM) has been used to treat HLP for a long time with its better therapeutic efficacy, less side effects and wider indications compared with western medicine. In this review, we summarized the pathogenesis of HLP, the research situation of disease-related targets, and the treatment progress of TCM by conducting literature research and sorting out relevant information, in order to provide reference for further research of HLP and prevent the occurrence of cardiovascular and cerebrovascular diseases.
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    4. Network pharmacology-based screening of the active ingredients and potential targets of the genus of Croton for application to lung cancer
    Shaochun Shi, Yeqing Du, Chunxin Zou, Qingbo Liu, Shaojiang Song
    亚洲传统医药    2019, 14 (5): 219-226.  
    摘要48)      PDF(pc) (997KB)(58)    收藏
    Lung cancer has been the most common cancer in the world for several decades, and it was also the most common cause of death from cancer. Despite the several advances in the last few years into treatment of lung cancer, the survival remains extremely low. There is an urgent need to discover viable leads that can be developed into new clinically therapeutic drugs with good treatment effects. The analysis of current reported literatures suggest that natural products possess strong inhibitory efficacy against lung cancer. The plants of Croton genus belonging to Euphorbiaceae family, are widely used as herbal medicine in the folk. Which are reported to have abilities to treat several cancer cell lines especially lung cancer, a successive study was carried out to identify selective anticancer agents from these plants specie. Herein we employed a network pharmacological approach to understand its multi-therapeutics potentiality in Croton genus against lung cancer. In total, the database of the compound was established based on the methods of network pharmacology prediction and the compound-disease target network was constructed. We believed that our study would provide important clues for finding novel drug inhibitors for lung cancer.
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    5. Network pharmacology-based virtual screening of natural products from Peperomia dindygulensis for the application to treat liver cancer
    Zhikang Duan, Han Zhang, Peng Zhao, Zhiyang Yan, Xiaoxiao Huang
    亚洲传统医药    2019, 14 (6): 253-259.  
    摘要36)      PDF(pc) (1448KB)(62)    收藏
    Traditional Chinese medicine plays an increasingly important role in cancer treatment for the property of the complex components and multi-targets. Peperomia dindygulensis, belonging to Piperaceae family, was proved to be effective to the treatment of cancer, but the action mechanism is incomprehensive. In this study, we employed molecular docking and network pharmacology methods to predict the effective compositions, potential target proteins and potential biological pathways. Six compounds were predicted to have potential activity for liver-cancer target proteins. Meanwhile, we analyzed the biological pathways based on compounds-target network, which may be play an important role in liver cancer. This article is presented to explore the active ingredients of P. dindygulensis and provide crucial material for the further research and development of the plant.
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    6. Overview of chemical constituents and pharmacological activities of Piper longum Linn.
    Liwei Lu, Le Zhou, Yuxi Wang, Zhuoyang Cheng, Jie Wang, Xiaoxiao Huang, Shaojian
    亚洲传统医药   
    7. Research review in the main chemical components and biological activities of Daphne aurantiaca Diels
    Yangyang Zhang, Zhiyang Yan, Hao Zhang, Guodong Yao, Xiaoxiao Huang
    亚洲传统医药    2019, 14 (6): 295-302.  
    摘要33)      PDF(pc) (1339KB)(50)    收藏
    Daphne aurantiaca Diels belongs to the Daphne L. genus of Thymelaeaceaen family and flavonoids, terpenoids, lignans, phenylpropanoids are the main chemical components isolated from this plant. And the extracts of Daphne aurantiaca Diels have been reported with multiple pharmacological activities and good development prospects, which have drawn enormous attention. Hence, this review summarized the research progress on the chemical components and the pharmacological effects of Daphne aurantiaca Diels.
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    8. Chemical constituents and pharmacological properties of Sarcandra glabra (Thunb.) Nakai.
    Hao Zhang, Peng Zhao, Yangyang Zhang, Xiaoxiao Huang, Shaojiang Song
    亚洲传统医药    2019, 14 (5): 237-246.  
    摘要31)      PDF(pc) (1414KB)(84)    收藏
    Sarcandra glabra (Thunb.) Nakai., belonging to Chloranthaceae genus of Sarcandra family, is widely used as the common Chinese herbal medicine in folk. As a traditional medicinal agent, a wide spectrum of chemical constituents have been isolated from the S.glabra, including sesquiterpenoids, triperpenoids, flavonoids, coumarins, phenolic acids and volatile oil. Modern pharmacological studies have shown that S.glabra has many biological activities such as anti-cancer, hepatoprotective activity, anti-inflammatory and anti-asthmatic activities. For the further development of this plant, the primary chemical constitutions of S.glabra and their activities have been summarized in this study.
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    9. A network-based pharmacology study on anti-hepatoma effect of the potential active constituents from Euphorbia fischeriana
    Peiyuan Yang, Zhuoyang Cheng, Peng Zhao, Xiaoxiao Huang
    亚洲传统医药   
    10. Virtual screening of active ingredients, potential targets and pathways from Elephantopus scaber L. against liver cancer based on network pharmacology
    Shuhui Dong, Ming Bai, Xiaoxiao Huang, Shaojiang Song
    亚洲传统医药    2019, 14 (6): 260-267.  
    摘要25)      PDF(pc) (1953KB)(38)    收藏
    Elephantopus scaber L., belonging to Elephantopus plant of Compositae, is widely used as the common Chinese herbal medicine in folk. According to the phytochemical investigations, E. scaber is used to treat several cancers, anemia and diarrhea on account of the property of the complex components and multi-targets. However, the underlying molecular mechanisms of herb remain unclear. In this report, network pharmacology method is used to analyze the relation among the small-molecule compounds of E. scaber, target proteins, biological pathways and liver cancer. The potential active compounds from the E. scaber, potential target proteins and the key pathways were predicted by network pharmacology models. We believe that our present study is useful to find novel lead compounds for liver cancer.
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    11. Preventive effect of essential oil of Cinnamomum camphora leaves against mice allergic contact dermatitis
    Haizhu Xing, Qian Lu, Nianyun Yang
    亚洲传统医药   
    12. Research review in the main chemical constituents and pharmacological effects of Daphne acutiloba Rehd.
    Tianming Lv, Rui Guo, Xiaoxiao Huang
    亚洲传统医药   
    13. Integrated evaluation of HPLC fingerprints for the quality control of Ginseng Yang Rong Wan by multi-wavelength fusion fingerprint method
    Hanxiao Chi, Guoxiang Sun
    亚洲传统医药    2019, 14 (4): 171-182.  
    摘要21)      PDF(pc) (1736KB)(18)    收藏
    The aim of this study was to develop comprehensive evaluation methods for the quality control of Ginseng Yang Rong Wan (RSYRW). Multi-wavelength fusion fingerprints were successfully developed by high-performance liquid chromatography, which avoided the one-sidedness of single fingerprinting. Characteristic fingerprints of thirty batches of samples were generated at five wavelengths and evaluated by quantified ratio fingerprint method (QRFM). The results showed that thirty batches of samples were classified into seven grades. The methods established in this paper were found suitable for the analysis of Ginseng Yang Rong Wan.
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    14. Network pharmacology-based prediction and verification of the molecular targets and pathways for Piper longum Linn. against liver cancer
    Liwei Lu, Jie Wang, Xiaoxiao Huang, Shaojiang Song
    亚洲传统医药    2019, 14 (4): 183-192.  
    摘要21)      PDF(pc) (1227KB)(34)    收藏
    Liver cancer is a common malignant tumor, which is one of the most common causes of cancer related deaths worldwide, specially, in China. Piper longum Linn. is a traditional Chinese medicine that is used to treat and prevent diseases in clinical practice, however, the active ingredients and potential targets of its action against liver cancer remain unclear. In this study, network pharmacology approach was used to identify active ingredients and the major targets of Piper longum against liver cancer. In addition, the key pathways were also predicted on the network pharmacology level, which might be beneficial to the chemical basis and pharmacological studies of this plant.
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    15. Research review on the main chemical constituents and pharmacological effects of Elephantopus scaber L.
    Shuhui Dong, Ming Bai, Xiaoxiao Huang, Shaojiang Song
    亚洲传统医药    2019, 14 (4): 202-212.  
    摘要14)      PDF(pc) (1724KB)(50)    收藏
    Elephantopus scaber L. belongs to Elephantopus plant of Compositae, is widely used as the common Chinese herbal medicine in folk. Phytochemical investigations of the E. scaber have resulted in the isolation of triterpennoids, sesquiterpene lactones, sesquiterpene phenols, steroids, flavones, anthraquinones, peptides, lipid compounds and aryl compounds. It possesses the effects of antibacterial, clearing away heat and detoxification, detumescence and diuresis, and is used for treating lung cancer, cervical cancer, liver cancer, nasopharyngeal cancer, breast cancer, anemia and diarrhea. The research progress in the chemical constituents of E. scaber and pharmacological effects are reviewed for better explore and utilize the E. scaber resource.
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    16. The Peperomia dindygulensis: a review of phytochemistry and pharmacology perspectives
    Zhikang Duan, Yuxi Wang, Xiaoxiao Huang
    亚洲传统医药    2019, 14 (4): 193-201.  
    摘要11)      PDF(pc) (1281KB)(29)    收藏
    Plant of peperomia dindygulensis Miq. is widely distributed in southern regions of China, which is traditionally used to treat cough, measles, abscesses and cancerous swelling in Chinese folk. As a traditional medicinal agent, a wide spectrum of chemical constituents have been isolated from the P. dindygulensis, including lignans, flavonoids, flavone glycosides, polyketides and other compounds. The research shows that these compounds exhibited bioactivities including antitumor and antiangiogenesis. Hence, this report is presented as a review centered on the chemical constituents and pharmacological activities of the P. dindygulensis, aiming at its further development and potential value.
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    17. Network pharmacology-based screening of the active ingredients and potential targets of the Patrinia villosa for application to Alzheimer’s disease
    Shuhui Dong, Zhikang Duan, Ming Bai, Xiaoxiao Huang, Shaojiang Song
    亚洲传统医药    2020, 15 (1): 1-7.  
    摘要6)      PDF(pc) (1271KB)(4)    收藏
    Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with global deterioration of intellectual function, including memory, learning, orientation, language, comprehension and judgment. Given the prevalence of AD and the lack of effective long-term therapies, there is a pressing need to discover viable leads that can be developed into clinically approved drugs with disease-modifying effects. The analysis of current reported literatures confirms the importance of Patrinia villosa J. as candidate against AD. Hence, the compound-disease target network based on the methods of network pharmacology prediction was established in this paper. The aim is to explore potential compounds with marked effect on AD in P. villosa. The result showed that the most effective compound in this plant might be threo-(7R,8R)-guaiacyl-glycerol-β-O-4′-dihydroconiferyl ether, and the most potential target might be Maltose-binding periplasmic.
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    18. Screening of potential active compounds in Daphne aurantiaca Diels against prostate cancer by Network pharmacology
    Yangyang Zhang, Jingjie Chen, Xiaoxiao Huang
    亚洲传统医药    2020, 15 (1): 24-31.  
    摘要6)      PDF(pc) (1399KB)(2)    收藏
    Daphne aurantiaca Diels belongs to the Daphne L.genus of Thymelaeaceaen family and flavonoids, terpenoids, lignans, phenylpropanoids are the main chemical components isolated from this plant. And the extracts of Daphne aurantiaca Diels have been reported with multiple pharmacological activities, such as anti-prostate cancer, anti-HIV, anti-microbial et al. and good development prospects, which have drawn enormous attention. However, its system-level researches of drug-target associations are not enough. Here we employed molecular docking and network pharmacology methods to predict the effective compositions of Daphne aurantiaca Diels and its potential target proteins against prostate cancer.
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    19. A theoretical study on the molecular structure and chemical reactivity of traditional Chinese medicine extract isopimpinellin
    Jian Zhang, Xiu Li
    亚洲传统医药    2020, 15 (1): 32-40.  
    摘要4)      PDF(pc) (1155KB)(1)    收藏
    Isopimpinellin (C13H10O5), alternative name 5,8-dimethoxypsoralen, is one of the furocoumarin compounds. This traditional Chinese medicine extract has attracted a great deal of attention in recent years due to its pharmacological properties, especially its antifungal effect. The main purpose of this study was to study the molecular structure and chemical reactivity of isopimpinellin using the density functional theory method. To understand and interpret the reactivity of isopimpinellin, various chemical reactivity descriptors such as chemical potential (μ), electronegativity (χ), chemical hardness (η) and electrophilicity (ω) and local reactivity index condensed Fukui function (fi(r)) have been calculated with five hybrid functionals PBE1PBE, MPW1PW91, B3LYP, X3LYP and B3PW91. These chemical reactivity descriptors indicate that the isopimpinellin molecule has a good antioxidant activity, which could be one of the reasons for its action as an effective antifungal drug. The condensed Fukui functions of isopimpinellin molecule provide a complete scheme of chemical reactivity of one molecule.
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    20. Evaluating the quality consistency of compound Liangmianzhen buccal tablets during accessories replacement by HPLC/UV related with its active profiling and UV dissolution profiles
    Yue Yu, Hanxiao Chi, Guoxiang Sun, Fangliang Yang, Wanyang Sun, Jiayue Hu, Yanhua Zhang
    亚洲传统医药    2020, 15 (1): 8-23.  
    摘要2)      PDF(pc) (2255KB)(1)    收藏
    Compound Liangmianzhen buccal tablet is a drug that exhibits notable effect on cough and diphtheria. Since the accessory has been changed, along with the difficulties in traditional Chinese drug-evaluation, it is imperative to set up a reliable method to evaluate the drug and ensure the quality consistency. First, the content of the Compound Liangmianzhen buccal tablets reflected by fingerprints were evaluated by the comprehensive linearly quantified fingerprint method and systematic quantified fingerprint method, in which thirteen fingerprint peaks was selected and gallic acid was chosen as the reference peak. The results of the two methods showed all batches in grades 1–3 of above good level with the qualitative similarities of Sl and Sm above 0.90, and the quantitative ones of Pl% and Pm% from 80%–120%, indicating all samples far qualified. Second, the measurement of antioxidant effect based on DPPH free radical clearance test has demonstrated the consistency between the old prescription group and the new ones and further dug up the major antioxidant compositions. Third, dissolution profiles at 190 to 400 nm that evaluate the curative effect consistency were evaluated by f2 and the correlation of the dissolution curve. In conclusion, the combination of 3 kinds of analysis methods can comprehensively assess the quality of the traditional Chinese drug and be served as a routine procedure to evaluate the herbal medicine consistency.
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