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    1. Main Chemical Constituents and pharmacological bioactive of Mimosa Pudica Linn
    Xiao-yu Song, Guo-dong Yao, Yan Zhang, Shao-jiang Song
    亚洲传统医药   
    2. Traditional Medicines Used in Differentiation Therapy of Myeloid Leukemia
    Rui Wang;Dandan Song;and Yongkui Jing*
    null    2006, 1 (1): 37-44.  
    摘要2532)      收藏
    Differentiation therapy has been successfully carried out in acute promyelocytic leukemia patients with
    treatments involving all-trans retinoic acid, a natural metabolite of vitamin A, and arsenic trioxide, a
    traditional medicine. Using human myeloid leukemia cell lines, many natural products isolated from
    traditional herb medicines have been found to have differentiation-induction ability. Compounds from
    traditional medicine with cell differentiation effects in leukemia cells are described in this communication.
    相关文章 | 多维度评价
    3. Studies on the Chemical Constituents of Desmodium styracifolium (Osbeck) Merr.
    Yuying Lin;Lingyi Kong*
    null    2006, 1 (1): 34-36.  
    摘要1335)      收藏
    To investigate the chemical constituents of Desmodium styracifolium (Osbeck) Merr. The compounds were
    isolated by column chromatography on silica gel, Sephadex LH-20 and HPLC. Their structures were
    identified by their physicochemical properties and spectral data. Thirteen compounds were isolated and
    identified as vicenin 1 (1), vicenin 2 (2), vicenin 3 (3), schaftoside (4), isovitexin (5), genistin (6), chrysoeriol (7),
    luteolin (8), salic acid (9), gentisic acid (10), orbicularin (11), uracil (12) and allantoin (13). Compounds 2, 6, 7,
    9~13 were isolated from this plant for the first time.
    相关文章 | 多维度评价
    4. Antiviral and Immunomodulatory Properties of Prunella vulgaris
    Chuen-lung Cheng;Hongxi Xu*
    null    2006, 1 (1): 45-48.  
    摘要341)      收藏
    Prunella vulgaris L. is a traditional Chinese medicine that has been used to treat a variety of ailments
    for hundreds of years. In recent decades, P. vulgaris has been shown to have antiviral and
    immunomodulatory properties. Potent antiviral effects of P. vulgaris polar fractions against HIV-1, HSV-1
    and HSV-2 have been reported. In addition, it has been shown that the extracts and chemical components
    can modulate various immune factors including histamine, TNF-alpha, IgG, IgG1, IgG2b, nitric oxide,
    LTB4, IFN-gamma, IL-2 in T cell activation and Src family protein kinase. This review will describe the
    novel discoveries and potential therapeutic applications of P. vulgaris extracts and its chemical components
    with regard to their antiviral and immunomodulatory effects.
    相关文章 | 多维度评价
    5. Simultaneous Determination of Five Bioactive Flavonoids in Hypericum japonicum Thunb by High-performance Liquid Chromatography
    Juan Li;Bo Jiang;Xiao Liu;Juan Zhang;Xiaohui Chen;Kaishun Bi *
    null    2007, 2 (2): 75-81.  
    摘要354)      收藏
    A simple reversed-phase liquid chromatographic method has been established for the simultaneous quantification of five bioactive flavonoids, i.e., taxifolin-7-O-rhamnoside, isoquercitrin, quercitrin, quercetin and kaempferol in Hypericum japonicum Thunb. Chromatographic separations were achieved on a Luna C18 column (250 mm×4.6 mm, 5 µm) with a gradient of methanol and 0.5 % aqueous acetic acid (v/v) as mobile phase and UV detection at 350 nm. The assay was reproducible with overall intra- and inter-day variation of less than 4.8 %. The mean recovery of the method was 99.8 % ± 2.5 %. Using the optimized method, 19 samples were analyzed. The results indicated that the developed HPLC assay could be readily utilized as a quality control method for Hypericum japonicum Thunb.
    相关文章 | 多维度评价
    6. Peptides from Plants: A New Source for Antitumor Drug Research
    Xudong Ma;Chunfu Wu;Wei Wang;Xiaobo Li *
    null    2006, 1 (2): 85-90.  
    摘要2148)      收藏
    Plants are an enormously rich source of peptides with the potential to be developed as anticancer agents, e.g. Violaceae, Rubiaceae, and
    Cucurbitaceae families and some marine plants. With the discovery of more and more peptides with antitumor activities, their mechanisms
    of action on tumors have also been shown to be varied. In this review, the recent studies on peptides from plant sources, including terrestrial
    and marine plants, are briefly discussed with a focus on their origins, antitumor activities and the possible mechanisms of actions in order to
    to provide a profile of important plant peptides.
    相关文章 | 多维度评价
    7. Several flavonoids from Capsella bursa-pastoris (L.) Medic.
    Ning Song;Wei Xu;Hongfeng Guan;Xiaoqiu Liu *;Yibo Wang;Xiaoling Nie
    null    2007, 2 (6): 218-222.  
    摘要2660)      收藏
    Nine flavonoids were isolated from the whole plant of Capsella bursa-pastoris (L.) Medic., and their structures were identified as tricin (1), kaempferol (2), quercetin (3), kaempferol-7-O-α-L- rhamnopyranoside (4), quercetin-3-O-β-D–glucopyranoside (5), quercetin-6-C-β-D-glucopyranoside (6), kaempferol-3-O-β-D-glucopyranosyl-7-O-α-L-rhamnopyranoside (7), quercetin-3-O-β-D-glucopyranosyl-7- O-α-L-rhamnopyranoside (8) and kaempferol-3-O-rutinoside (9) on the basis of chemical and physicochemical evidence. All the compounds were obtained from this genus for the first time.
    相关文章 | 多维度评价
    8. Simultaneous Determination of the 6-Methyl-5-hepten-2-one, Limonene, Linalool and Citral in Essential Oil from Litsea cubeba (Lour.) Pers by Capillary Gas Chromatography
    Shuanghui Yu;Xiaohui Chen;Ling Tong;Kaishun Bi *
    null    2007, 2 (2): 66-69.  
    摘要1756)      收藏
    A simple and fast Capillary Gas Chromatography (CGC) method was established for the simultaneous determination of four major components, namely 6-methyl-5-hepten-2-one, limonene, linalool and citral in essential oil from Litsea cubeba (Lour.) Pers. The CGC analysis was performed on a 30 m × 0.50 mm i.d. SE-54 capillary column, and was carried out with temperature programs by using nitrogen as carrier gas. The good linear regression relationship was obtained over the range of 0.030–1.502 mg·mL-1 (r = 0.9999) for 6-methyl-5-hepten-2-one, 0.018–0.894 mg·mL-1 (r = 0.9997) for Limonene, 0.016–0.809 mg·mL-1 (r = 0.9997) for Linalool , 0.079–3.962 mg·mL-1 (r = 0.9999) for citral, respectively. The method is accurate with overall intra-day variation and repeatability less than 5 % and the recovery more than 95 %. The contents of sample from different regions varied greatly. CGC was proved to be a quick and informative tool for analysis of essential oil from Litsea cubeba (Lour.) Pers. The method was successfully applied to analyze four major components.
    相关文章 | 多维度评价
    9. Anti-tumor Activity of the Compound Recipe Radix Sophorae Flavescentis for Injection in vivo and in vitro
    Honghao Zheng;Xiaomian Zhou *;Enlong Ma;Yinglin Cao and Yi Dai
    null    2007, 2 (1): 19-22.  
    摘要1228)      收藏
    The purpose of these experiments is to investigate the anti-tumor effect of the compound recipe Radix Sophorae Flavescentis for injection (CRS) in vitro and in vivo. The S180 , H22 , Lewis lung tumor models were established in mice and the inhibition rate of tumor growth was calculated by weighing the tumor after CRS treatment. MTT assay was used to examine its effect on HeLa and HepG-2 cells. CRS (dose: 1.6, 3.2, 6.4 g·mL-1) produced a clear inhibitory effect on the growth of S180, H22, Lewis in tumor-bearing mice, and the inhibition rate was more than 35 % (P < 0.01 vs. control group). The CRS, at a dose of 1-0.25 g·mL-1, significantly inhibited the growth of HeLa and HepG-2 cells in a dose-dependent manner. Following these results, it appears that CRS has marked inhibitory effects on tumor growth in vitro and in vivo.
    相关文章 | 多维度评价
    10. Simultaneous Determination of Four Main Compounds in Siwu Heji by High-performance Liquid Chromatography
    Lingdan Meng;XiaoHui Chen;Yan Yao and KaiShun Bi*
    null    2006, 1 (1): 11-14.  
    摘要2170)      收藏
    A simple, rapid and reliable high-performance liquid chromatography (HPLC) method has been
    developed for the first time to simultaneously determine the four major ingredients, namely gallic acid,
    Albiflorin, paeoniflorin and ferulic acid, in an oral solution of Siwu Heji. The separation of these marker
    compounds was achieved on an Extend-C18 column with gradient elution using acetonitrile and aqueous
    phosphoric acid as the mobile phase. The assay was linear over the range (μg) 0.066-0.598 for gallic acid,
    0.171-1.537 for Albiflorin, 0.220-1.982 for paeoniflorin and 0.010-0.091 for ferulic acid. The average sample
    recovery (%) was 101.6, 100.2, 98.8 and 99.1 for these four constituents, respectively. The results
    demonstrated variations in the content of each of the marker compounds in different lots, indicating that
    careful quality control of the bioactive ingredients in Siwu Heji is necessary to ensure the uniformity of their
    extraction procedures. This assay is suitable for the quality control of Siwu Heji.
    相关文章 | 多维度评价
    11. Comparison of the Effects of Long-term and Short-term Treatment of Powder from Soft-shell Turtle on Bone Loss and Reduction in Bone Strength in OVX Rats
    Jun Yin*;Zhihui Liu;Subehan;Junya Ueda;Katsumichi Matsushige;and Shigetoshi Kadota
    null    2006, 1 (1): 15-19.  
    摘要2353)      收藏
    The comparative effects of long-term and short-term treatment with the powder of soft-shell turtle
    (Trionyx sinensis)( SST) on the proximal tibiae of ovariectomized (OVX) rats were investigated by scanning
    bones using peripheral quantitative computed tomography (pQCT). Initially, oral administration of SST (100
    and 500 mg/kg) 3 times weekly was carried out for 6 weeks without any effect on preventing bone loss except
    for inhibiting the reduction in bone mineral density (BMD) in cancellous bone; then SST (100 and 200 mg/kg)
    3 times weekly was administered for six months and in the high dose group, it prevented the reduction in bone
    mineral content (BMC) in total bone, BMC and bone mineral density (BMD) in cortical bone and bone
    strength indexes induced by OVX, in a dose-dependent manner without any side effects on the uterus.
    相关文章 | 多维度评价
    12. Antidiabetic activities of methanol-derived extract of Dorstenia picta twigs in normal and streptozotocin-induced diabetic rats
    Ngueguim Tsofack Florence;Dimo Théophile *;Dzeufiet Djomeni Paul Désiré;Vouffo Bertin;Dongo Etienne;Renaud Beauwens;Asongalem Acha Emmanuel;Zapfack Louis;Kamtchouing Pierre
    null    2007, 2 (4): 140-148.  
    摘要2482)      收藏
    We investigated the effect of Dorstenia picta methanolic residue extract on blood glucose levels and some biochemical parameters in normal and streptozotocin-induced diabetic rats. Single oral administration of the extract at a dose of 75 mg/kg, significantly, reduced the blood glucose levels by 23.74 % and 29.79 %, in normal and diabetic rats, respectively after 5 hours. In glucose tolerance test (OGTT), the extract (75 mg/kg) produced a significant blood glucose lowering effect. Repeated doses of distilled water, insulin, 75 and 150 mg/kg of extract were administered orally and once daily to normal and streptozotocin-induced diabetic rats for 14 consecutive days. D. picta and insulin prevented body weight lost, polyphagia and polydipsia, as well as a significant (p <0.01) decreased in blood glucose at the dose of 75 mg/kg (53.88 %) and 150 mg/kg (81.96 %). There was also significant decrease of elevated serum cholesterol and triglycerides in both normal and diabetic rats. At these doses, reductions of plasma alanine and aspartate transaminase levels were recorded in both normal and diabetic rats but creatinine and total protein remained unchanged. These data indicated that D. picta treatment may improve glucose homeostasis in streptozotocin-induced diabetes which could be linked to insulin-like activity and ameliorate kidney and liver functions. D. picta twigs have antidiabetic effect and could be a potential source of new oral antidiabetic drug.
    相关文章 | 多维度评价
    13. Quality Control of TCMs Using a Chromatographic Fingerprint
    Ying Jia;Xiaojie Tan;Qing Li;Weiming Cheng;Xiaohui Chen;and Kaishun Bi*
    null    2006, 1 (2): 94-100.  
    摘要1223)      收藏
    This paper summarizes the application of a chromatographic fingerprint for the quality control of TCMs (traditional Chinese medicines) and
    illustrates its application to TCM quality control by taking Flos Chrysanthemi Indici injection and Danhong injectable powder as examples.
    相关文章 | 多维度评价
    14. A molecular Biological Method for Screening and Evaluating the Traditional Chinese Medicine Used in Pi-deficiency Therapy Involving Intestinal microflora
    Jing Kong;Xiaobo Li*;and Chunfu Wu
    null    2006, 1 (1): 1-6.  
    摘要2406)      收藏
    Pi-deficiency (“Spleen” deficiency), a common syndrome seen in clinics practising Traditional Chinese
    Medicine (TCM), is one of the main digestive system diseases and is associated with gastrointestinal
    microflora. In this study, a molecular biology method of evaluating and screening Pi-deficiency therapy and
    other TCM related to intestinal microflora was established. The intestinal microflora were isolated from mice
    feces for analysis; the total DNA extracted from the fecal intestinal microflora and its Enterobacterial
    Repetitive Intergenic Consensus PCR (ERIC-PCR) protocol were studied. The Pi-deficiency model involved
    treatment with an aqueous extract of Radix et Rhizoma Rhei and Reserpine. An analysis and comparison of
    the ERIC-PCR fingerprints of intestinal microflora of mice feces obtained from healthy animals, Pi-deficient
    animals and those cured by decoctions of Si-jun-zi-tang and Li-zhong-tang were carried out . The
    ERIC-PCR fingerprints showed changes in all the intestinal microflora, and the method was found to be
    an efficient method for evaluating and screening Pi-deficiency therapy and the other TCM acting on intestinal
    microflora.
    相关文章 | 多维度评价
    15. Several Phenolic Acids From The Fruit of Capparis spinosa
    Yang Yu;Huiyuan Gao;Zhishu Tang;Xiaomei Song;Lijun Wu*
    null    2006, 1 (2): 101-104.  
    摘要1415)      收藏

    Eight compounds were isolated from the fruit of Capparis spinosa by chromatographic methods and their structures were established by spectroscopic methods as β-sitosterol (1), vanillic acid (2), p-hydroxybenzoic acid (3), protocatechuric acid (4), daucosterol (5), uracil (6), butanedioic acid (7) and uridine (8) respectively. This is the first time that compounds 2-8 have been isolated from the Capparis genus.
    相关文章 | 多维度评价
    16. Preparation of Self-emulsifying Drug Delivery Systems of Ginkgo biloba Extracts and In vitro Dissolution Studies
    Jingling Tang;Jin Sun;Fude Cui;Zhonggui He*
    null    2006, 1 (3-4): 138-141.  
    摘要2570)      收藏
    Self-emulsifying drug delivery systems ( SEDDS ) are mixtures of oils, surfactants and cosurfactants, which efficiently improve dissolution of sparingly soluble drugs by rapid self-emulsification. Ginkgo biloba extract ( GBE ) has become a widely used herbal remedy for increasing cognitive function in the elderly. Based on a pseudo-ternary phase diagram and in vitro self-emulsification efficiency, the optimum formulation
    was obtained for GBE. The in vitro dissolution behavior of SEDDS was measured, taking the tablets as reference. As for the optimum formulation, ethyl oleate, T50C50 ( 50 % Tween 80-50 % Cremophor EL35 ) and 1, 2-propanediol were selected as the oil phase, emulsifier and
    cosolvent, respectively, in proportions 45: 45: 10. The content of GBE was fixed at 12.5 % w/w of the vehicle. The in vitro dissolution rates of the active components of GBE from optimal SEDDS were significantly faster than those of the GBE tablets.
    相关文章 | 多维度评价
    17. Determination of Terazosin in Human Plasma by High Performance Liquid Chromatography with Ultraviolet Detection
    Dandan Chen *;Chunjie Zhao
    null    2006, 1 (2): 52-54.  
    摘要2246)      收藏
    A simple, sensitive and reproducible high performance liquid chromatography (HPLC) method with ultraviolet (UV) detection has been developed for the determination of terazosin in human plasma. The procedure involved a liquid – liquid extraction of terazosin from human
    plasma with ether. Separation was achieved with a reversed-phase C18 column (250 mm × 4.6 mm, 5 μm) employing UV detection at 254
    nm. The mobile phase consisted of acetonitrile – tetrahydrofuran - 0.01 mol/l potassium dihydrogenphosphate solution (15:5:80, v/v) at a
    flow rate of 1.0 ml/min. The total run time was 8.0 min. The standard curve was linear over a working range of 10 – 400 ng/ml and gave an
    average correlation coefficient of 0.9903 during validation. The limit of quantification (LOQ) of this method was 10 ng/ml. The inter-day and
    intra-day precisions were between 7.7 % – 2.5 % and 10.3 % – 2.6 %, respectively.The method was found to be precise, accurate and specific
    during the study and, hence, it is suitable for use in pharmacokinetic studies of terazosin.
    相关文章 | 多维度评价
    18. Chemical Constituents of Active Extracts from the Seeds of Nigella glandulifera Freyn
    Junjun Ni;Huiyuan Gao;Bohang Sun;Zhexing Wang;and Lijun Wu*
    null    2006, 1 (2): 69-72.  
    摘要1671)      收藏
    Five known compounds, 3-O-[α-L-rhamnopyranosyl-(1→2)-α-L-arabinpyranosyl]-hederagenin (1), 3-O-[β-D-xylopyranosyl- (1→3)- α - L -
    rhamnopyranosyl - (1→2) - α - L- arabinpyranosyl] - hederagenin (2), 3 – O – [ α – L – rhamnopyranosyl – (1→2) – α - L -arabinpyranosyl]-
    28-O-β-D-glucopyranosyl hederagenin (3), 3-O-[α-L-rhamnopyranosyl-(1→2)-α-L-arabinpyranosyl]-28-O- [β-D-glucopyranosyl-(1→6)-β-Dglucopyranosyl]
    hederagenin (4), and 3-O-[α-L-rhamnopyranosyl-(1→2)-α-L-arabinpyranosyl] -28-O-[α-L-rhamnopyranosyl-(1→4)-β-Dglucopyranosyl-(
    1→6)-β-D-glucopyranosyl] hederagenin (5), were isolated from the active extracts of the seeds of Nigella glandulifera Freyn.
    Compounds (3), (4), (5) were isolated from the plants of the Nigella genus for the first time.
    相关文章 | 多维度评价
    19. Anti-osteoporotic Effects of Medicinal Herbs and their Mechanisms of Action
    Yan Zhang;Mansau Wong;Chunfu Wu*
    null    2006, 1 (3-4): 105-111.  
    摘要1312)      收藏
    This article reviews the recent pharmacological research of medicinal herbs on osteoporosis, especially induced by estrogen deficiency, in animal model. The information will provide the reference for future clinical drug research and development on anti-osteoporosis as the
    alternative to synthetic medicine.
    相关文章 | 多维度评价
    20. Pharmacological evaluation of some fungitoxic essential oils
    Pramila Tripathi *;N. K. Dubey ;A. K. Shukla
    null    2007, 2 (6): 239-243.  
    摘要3151)      收藏
    The present study comprises pharmacological trials with the essential oils of Mentha arvensis, Ocimum canum and Zingiber officinale which have been found to exhibit pronounced fungitoxic effects on several types of fungi which are toxic to some crops. Analysies of the blood and serum of albino rats fed with an oil-supplemented diet for sixty days did not reveal significant variations in the levels of hemoglobin, total blood glucose, protein, cholesterol, urea, serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, and alkaline phosphatase nor in differential leucocyte counts, in comparison to rats fed a normal rat diet. These essential oils, thus, can be recommended as safe antifungal agents in so far as the parameters tested indicate.
    相关文章 | 多维度评价
    21. Studies on Antioxidant Activity and Chemical Constituents of Artemisia halodendron
    Yannian Wang *;Jun Yin;Yanjiang Qiao;Honggui Zhang and Xin Lu
    null    2007, 2 (1): 30-33.  
    摘要1320)      收藏
    The ethanol extracts of the crude drug Artemisia halodendron were divided into four fractions by liquid-liquid partitions by the increasing polarity. Among them, the EtOAc fractions showed the strongest scavenging activity to DPPH free radicals. The constituents of Artemisia halodendron were investigated. Nine compounds were isolated by column chromatography on silica gel and polyamide. Their structures were identified as: arcapillin (1), isorhamnetin-3-O-glucopyranoside (2), p-hydroxyl-acetophenone (3), caffeic acid (4), p-hydroxyl- cinnamicacid (5), isorhamnetin (6), n-hexadecanoic acid (7), cirsilineol (8), pentacosanol (9). Compound (1), (3) ~ (7) and (9) were isolated from this plant for the first time
    相关文章 | 多维度评价
    22. C-glycosylfavones and aromatic glycosides from Campylotropis hirtella (Franch.) Schindl.
    Ping Wen;Huiying Han;Ruwei Wang;Naili Wang;*;Xinsheng Yao
    null    2007, 2 (4): 149-153.  
    摘要2347)      收藏
    Five C-glycosylfavones and three aromatic glycosides were isolated from Campylotropis hirtella (Franch.) Schindl using a variety of chromatographic techniques. The structures of these compounds were identified by means of physico-chemical properties and spectral data. They were orietin (1), isoorientin (2), vitexin (3), isovitexin (4), vitexin-2’’-xyloside (5), benzyl-O-β-D-glucopyranoside (6), 3,4,5-trimethoxyphenyl-O-β-D-glucopyranoside (7), and (E)-resveratrol 3,5-O-β-D-diglucopyranoside (8), respectively. All of these compounds were obtained from the genus Campylotropis for the first time.
    相关文章 | 多维度评价
    23. The Quality Control of the Effective Fraction from Dioscorea spongiosa
    Yong Wang;Yang Liu;Zhihui Liu and Jun Yin *
    null    2007, 2 (1): 12-18.  
    摘要1386)      收藏
    It is of great importance to establish systematic quality control methods for the effective fractions of herbal medicines as part of the modernization programme for Traditional Chinese Medicines. The effective fraction from Dioscorea spongiosa and its major active component, methyl protodioscin, have been reported to have antiosteoporotic activity. In the present study, the quantitative analyses of the total saponins and methyl protodioscin of the effective fraction from Dioscorea spongiosa were established by vanillin-perchloric acid colorimetry and HPLC, respectively. The content of total saponins in three batches of effective fractions, determined by colorimetry with methyl protodioscin as the reference substance in this study, was more than 55%. The established HPLC method, which has good linearity, precision, and reproducibility as well as being highly stable and sensitive, is practical and reliable for the quality control of Dioscorea spongiosa. The combination of both methods may be also helpful for the effective fractions of other species of Dioscorea in terms of their systematic evaluation and quality control.
    相关文章 | 多维度评价
    24. Ameliorating the effects of acetaminophen-induced hepatotoxicity in rats with African red palm oil extract
    A. A. Adeneye *;A. S. Benebo
    null    2007, 2 (6): 244-249.  
    摘要2395)      收藏
    The hepatoprotective activities and possible mechanisms of action of African red palm oil extract (ARPO), an oily preparation of Elaeis guineensis Jacq., were investigated in acute hepatocellular injuries induced by 800 mg/kg of acetaminophen (APAP [this does not seem to me to be a rerasonable abbreviation. APHEN or ACPH might be better.]) injected intraperitoneally (IP) into Wistar rats. Its hepatoprotective activities were monitored by assaying for serum alanine (ALT) and aspartate (AST) aminotransferases and alkaline phosphatase (ALP) and histopathological hepatic lesions 24 hr post-APAP induction. Each group of six rats was given 1.5 mL/kg ARPO IP co-administered with 800 mg/kg APAP IP and then treated with 1.5 mL/kg IP ARPO at 1 and 2 hr, respectively [I do not understand the “respectively” here. Were the rats treated at both 1 and 2 hr or one group treated at 1 hr and the other at 2? Reconfigure the sentence (or 2 sentences) to make this clear and possibly the “respectively” will not be needed.]. ARPO treatment significantly attenuated (p<0.05) the acute elevations of the liver enzymes and hepatocytes necrosis in both groups due to the APAP induction. However, ARPO was not hepatoprotective in rats pretreated with 1.5 mL/kg of ARPO at 12 hr pre-APAP induction and 4 hr post APAP induction. These results suggest that ARPO ameliorates the effects of APAP-induced hepatotoxicity when administered up to 2 hr post APAP induction, but does not have prophylactic activity.
    相关文章 | 多维度评价
    25. A Novel Sesquiterpene from Curcuma longa
    Chunyan Liu;Bohang Sun;Jian Huang;Huiyuan Gao;Shaodun Wen;Lijun Wu *
    null    2007, 2 (2): 82-84.  
    摘要1219)      收藏
    A novel compound was isolated from the EtOH extract of Curcuma longa L. by chromatographic methods and its structure was established by spectroscopic methods as curcumin L.
    相关文章 | 多维度评价
    26. Structures and Anti-histamine Activity of Chalcones & Aurones Compounds from Bidens parviflora Willd.
    Jue Wang;Naili Wang *;Xinsheng Yao and Susumu Kitanaka
    null    2007, 2 (1): 23-29.  
    摘要2060)      收藏
    Using the effects on histamine release of Bidens parviflora Willd. to identify biologically active compounds. Five chalcones, two flavanones and two aurones were isolated and identified as 2′-hydroxy-3, 4, 4′–trimethoxy chalconee (I), 4, 2′,4′,6′-tetramethoxy dihydrochalcone (II), 3, 4, 2′, 4′, 6′-pentamethoxy dihydrochalcone (III), 7, 3′, 4′-trihydroxy flavanones (IV), 3′, 4′-dihydroxy flavanones 7-O-β-D-glucoside (V), 3, 4, 2′, -trihydroxy chalcone 4′-O-β-D-glucoside (VI), 3-methoxy-4, 2′, 3′-trihydroxy chalcone 4′-O-β-D-glucoside (VII), sulfuretin 6-O-β-D-glucoside (VIII), and maritimetin 7-O-β-D-glucoside (IX). Compounds I-VII were obtained from Bidens parviflora Willd. for the first time , while compound III was a new dihydrochalcone, and I and II were isolated from natural sources for the first time. The chalcones glucosides and aurones glucosides exhibited activity in anti-allergic assays of histamine in rat mast cells induced by an antigen-antibody reaction and the inhibitory activity of NO production by macrophages is compared and discussed.
    相关文章 | 多维度评价
    27. A New Tetrahydrofuran Lignan Glycoside from Viscum coloratum
    Jun Yin *;Xiaokang Wang;Zhihui Liu;Shigetoshi Kadota
    null    2007, 2 (2): 58-60.  
    摘要1148)      收藏
    A new tetrahydrofuran lignan glycoside, named viscoloratin, was isolated from the stem of Viscum coloratum (Komar.) Nakai. Its structure was elucidated by spectroscopic analysis and chemical methods.
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    28. Analgesic Peptides in Buthus martensii Karsch: A Traditional Chinese Animal Medicine
    Jianhua Shao;Rong Zhang;Xin Ge;Bin Yang;Jinghai Zhang*
    null    2007, 2 (2): 45-50.  
    摘要2557)      收藏
    Buthus martensii Karsch has been used as a traditional Chinese medicine for more than 2000 years for its outstanding pharmaceutical effects. With the development of modern separation and purification technology, more and more peptides have been isolated from the venoms of Buthus martensii Karsch. And the progresses in biomass spectrum, bioinformation, and other related technologies make it possible to study the structure-function relationships deeply. Recent progress of analgesic peptides in Buthus martensii Karsch was reviewed, involving their structural characters, bioactive sites, eletrophysiological characters, et al. We speculated that this kind of peptides would become a new class of painkiller for their species-specificity, high selectivity and little dependence.
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    29. An NMR Study of a Phenyl Propanoid-substituted Catechin from Polygonum bistorta
    Xiaoqiu Liu*;Weiwei Li;Huiming Hua;Wen Li;Fakui Chen;Lijun Wu
    null    2006, 1 (2): 73-75.  
    摘要1193)      收藏
    A flavan-3-ol, cinchonain, has been isolated from the rhizome of Polygonum bistorta L. for the first time, 2D shift -correlated NMR techniques
    were used for the signal assignment.
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    30. Determination of Pyrethroid Pesticide Residues in Traditional Chinese Medicines by Gas Chromatography-Mass Spectrometry with Negative Chemical Ionization
    He Zhu;Yuehu Pei*;Aihua Song
    null    2006, 1 (2): 55-59.  
    摘要267)      收藏
    A method is described for determining and screening 5 pyrethroid pesticides in 48 kinds of traditional Chinese medicines, each as 10 batches,
    by gas chromatography–mass spectrometry (GC-MS) with negative chemical ionization (NCI). The method had been tested for 5 pesticides in
    6 traditional Chinese medicinal plants with limits of detection (LODs) from 0.5ppb to 5ppb. The recoveries of the 5 pesticides in the 6 plants
    ranged from 70% to 120% with relative standard deviations < 10% . The method is rapid, sensitive and suitable for the analysis of large
    numbers of samples at the same time.
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    31. Morphological and Molecular Identification of Aspergillus versicolor D&#8722;1 with Selective Reduction Ability
    Hong Guan;Li Yang;Jun Guo;Xiaonan Ma;Huimin Wang;Song You *
    null    2007, 2 (1): 39-44.  
    摘要1037)      收藏
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    32. Identification of Water-soluble Components, That Are not Saponins, from Dioscorea nipponica Mak.
    Jiayong Zhang;Haifeng Chen;Naili Wang;*;Xinsheng Yao;
    null    2007, 2 (2): 70-74.  
    摘要1242)      收藏
    The water-soluble components belonging to non-saponins from Dioscorea nipponica Mak. were isolated and structurally identified. Solvent extraction and column chromatography were used to isolate the compounds and physico-chemical constants and spectroscopic analysis were employed for structural identification. Seven compounds were isolated and elucidated as benzyl 1-O-β-D-glucopyranoside (1), leonuriside A (2), Icariside D2 (3), pyrocatechol 1-O-β-D-glucopyranoside (4), (+) syringaresinol-4-O-β-D-glucopyranoside (5), cyclo-(Leu-Tyr) (6) and adenosine (7). All of these compounds were obtained from Diosorea for the first time.
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    33. Flavonol glycosides from Castanea mollissima Blume
    Dongsong Zhang;Huiyuan Gao;Libo Wang;Dan Li;Masonori Kuroyanagi ;Lijun Wu *
    null    2007, 2 (6): 229-234.  
    摘要2404)      收藏
    Three flavonol glycosides, kaempferol-3-O-[6"-O-(E)-p-coumaroyl]-β-D-galactopyranoside (1), kaempferol-3-O-[6"-O-(E)-p-coumaroyl]-β-D-glucopyranoside (2) and kaempferol-3-O-[6", 2"-di-O-(E)-p-coumaroyl]-β-D-glucopyranoside (3), were isolated from the seeds of Castanea mollissima Blume. Their structures, especially the sugar units, were elucidated based on the spectroscopic evidence, chemical reactions and CD experiments. Compounds 1 and 3 were isolated from Castanea for the first time. Compound 2 was isolated from this plant for the first time.
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    34. A novel natural dammarane-type triterpene saponin from the leaves of Panax ginseng
    Xiaohui Tang;Xiujia Sun;Jian Huang;Lijun Wu *
    null    2007, 2 (3): 124-126.  
    摘要1112)      收藏
    Ginsenoside RS-9, a novel natural product, was isolated from the leaves of Panax ginseng C.A. Meyer by column chromatography. Its structure was determined as β-D-glucopyranoside, (3β, 12β)-12, 20-dihydroxydammar-24-en-3-yl, 6-acetate, by spectroscopic methods.
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    35. A new flavonoid glycoside from the seeds of Fagopyrum tataricum
    Yaqing Wu;Bohang Sun;Jian Huang;Huiyuan Gao;Lijun Wu*
    null    2007, 2 (5): 202-205.  
    摘要1160)      收藏
    A new flavonoid glycoside, characterized as quercetin 3-O-rutinoside-3′-O-β-glucopyranoside (1), has been isolated from the seeds of Fagopyrum tataricum by chromatographic methods. Detailed HMQC and HMBC have been provided for the new compound.
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    36. Anti-tumor Constituents from Paris polyphylla
    Yu Wang;Wenyuan Gao *;Xinqiao Liu;Yutong Zuo;Haixia Chen;and Hongquan Duan
    null    2006, 1 (1): 7-10.  
    摘要1165)      收藏
    To study the anti-tumor constituents from the rhizome of Paris polyphylla. The compounds were isolated
    and purified by several chromatographic techniques and identified by chemicophysical properties and
    spectral analyses. The anti-tumor experiment in vitro, the MTT method was applied to select active
    constituents from Paris polyphalla. Eight compounds were obtained and identified as Falcarindiol (1),β
    -ecdysterone (2), and six known saponins. Falcarindiol (1) was isolated from this plant for the first time, both
    compounds 1 and 3-8 showed significant anti-tumor activities.
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    37. A New Triterpenoidal Saponin from the Buds of Aralia elata (Miq.) Seem.
    Li Li;Shaojiang Song *;Zhenxing Liang and Suixu Xu
    null    2007, 2 (1): 1-4.  
    摘要1160)      收藏
    A new saponin, named as Congmuyanoside I {3-O-[β-D-glucopyranosyl (1→3)-β-D-glucopyranosyl] caulophyllogenin}, together with three known compounds, Congmuyanoside A, Congmuyenoside B and 3-O-[β-D-glucopyranosyl (1→2)-β-D-glucopyranosyl] hederagenin were isolated in continuing studies on the buds of Aralia elata (Miq.) Seem. The structure of the new saponin was assigned by NMR spectral data using various 2D techniques.
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    38. Application of HSQC-TOCSY to the Analysis of Saponins
    Yue Cong*;Wen Li;Changda Liu;Jinhu Wang;and Xian Li
    null    2006, 1 (1): 20-24.  
    摘要1320)      收藏
    HSQC-TOCSY is a useful 2D NMR method for determining the structures of organic molecules that
    possess independent spin systems. In this paper, 5 compounds have been isolated from the leaves and stems of
    Panax quinquefolium L.. and they are used to demonstrate the application of this technique. The 13C and 1H
    chemical shifts of the sugar moiety of the 5 compounds were assigned accurately.
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    39. Quality Evaluation of Echinacea Species Cultivated in China
    Lingfeng Kong;Dan Yuan*;Ying Chen;Jun Yin;Toshiaki Makino;Toshio Uno;Shaohui Zhang;Yoshihiro Kano
    null    2006, 1 (1): 25-30.  
    摘要2265)      收藏
    For the quality evaluation of the raw materials of Echinacea species cultivated in China, the contents of 5
    marker compounds in 31 samples botanically identified as E. purpurea (L.) MOENCH., E. angustifolia DC. or
    E. pallida (NUTT.) NUTT. were determined by HPLC; these were 3 caffeoyl conjugates, i.e. cichoric acid,
    echinacoside and chlorogenic acid, and two stereo-isomers of alkamide, i.e. dodeca-2E,4E,8Z,10E/Ztetraenoic
    acid isobutylamide. The samples from three Echinacea species showed a great difference in the
    chemical composition of the caffeoyl phenols. The contents of 5 marker compounds in 7 samples of E.
    purpurea were lower in comparison with those from German or Australian sources described in previous
    reports. A detailed analysis on the distribution of the 5 marker compounds in different parts of E. purpure as
    well as their variations during flowering demonstrated that the capitula accumulated high concentrations of
    the caffeoyl phenols and alkamides, and that the content of caffeoyl phenols varied markedly with the
    different seasons. These results may be helpful not only for the standardization of the raw materials of E.
    purpurea as well as other two E. species from Chinese markets, but also in helping with their selection and
    cultivation in China.
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    40. Iridoid and phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl.
    Bin Chen;Naili Wang;Jinghui Huang;Xinsheng Yao;*
    null    2007, 2 (3): 118-123.  
    摘要2350)      收藏
    Seven iridoid and phenylpropanoid glycosides were isolated from the roots of Scrophularia ningpoensis Hemsl. by various chromatographic techniques. Then they were characterized by physico-chemical properties and spectral data as 8-O-(p-coumaroyl)-harpagide (1), 8-O-feruloylharpagide (2), harpagide (3), cis-acteoside (4), sibirioside A (5), acretoside (6), and 6-O-caffeoyl-β-D-fructofuranosyl-(2→1)-α-D-glucopyranoside (7). Compound 5 was obtained from this plant for the first time and compounds 1, 6, 7 were obtained for the first time from the Scrophularia L.
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