Structures and Anti-histamine Activity of Chalcones & Aurones Compounds from Bidens parviflora Willd.
2007, 2 (1):
Using the effects on histamine release of Bidens parviflora Willd. to identify biologically active compounds. Five chalcones, two flavanones and two aurones were isolated and identified as 2′-hydroxy-3, 4, 4′–trimethoxy chalconee (I), 4, 2′,4′,6′-tetramethoxy dihydrochalcone (II), 3, 4, 2′, 4′, 6′-pentamethoxy dihydrochalcone (III), 7, 3′, 4′-trihydroxy flavanones (IV), 3′, 4′-dihydroxy flavanones 7-O-β-D-glucoside (V), 3, 4, 2′, -trihydroxy chalcone 4′-O-β-D-glucoside (VI), 3-methoxy-4, 2′, 3′-trihydroxy chalcone 4′-O-β-D-glucoside (VII), sulfuretin 6-O-β-D-glucoside (VIII), and maritimetin 7-O-β-D-glucoside (IX). Compounds I-VII were obtained from Bidens parviflora Willd. for the first time , while compound III was a new dihydrochalcone, and I and II were isolated from natural sources for the first time. The chalcones glucosides and aurones glucosides exhibited activity in anti-allergic assays of histamine in rat mast cells induced by an antigen-antibody reaction and the inhibitory activity of NO production by macrophages is compared and discussed.