多酚杂志

本期目录

2024年, 第6卷, 第1期　刊出日期：2024-03-10 上一期   

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Preparation and release of curcumin/silk fibroin/sodium alginate film Yerong Yuan, Jun’an Zheng, Zunchao Liu, Wei Li, Jiaqing Cao, Xiangrong Zhang 2024 (1):  1-10.  摘要 ( 32 )   PDF(1550KB) ( 16 )   Abstract The aim of this study was to prepare silk fibroin/sodium alginate composite film containing curcumin by casting method. Orthogonal test was used to optimize the formulation according to the values of tensile strength and elongation at break. The release of curcumin in the optimal film was studied in order to explore its application as wound dressing. The results showed that the optimum composition of curcumin/silk fibroin/sodium alginate composite film was as follows: Silk fibroin (70 mg/mL) 2.7 g, sodium alginate (24 mg/mL) 0.84 g, span 40 (5.0 mg/mL) 0.4 g, glycerol (3.75%, V/V) 3 mL, curcumin (0.2 mg/mL) 0.016 g. The optimum film showed the tensile strength and the elongation at break was (0.628 ± 0.032) MPa and (0.794 ± 0.046) %, respectively. 相关文章 | 计量指标

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The mechanism of Callistephus chinensis flavonoid compounds in the treatment of diabetes using network pharmacology and molecular docking Mingyuan Yuan, Xiaoli Wang, Ziqi Sun, Xiaoshu Zhang 2024 (1):  11-19.  摘要 ( 27 )   PDF(4622KB) ( 23 )   Abstract The purpose of this project is used for exploring the mechanism of Callistephus chinensis in the treatment of diabetes by network pharmacology and molecular docking methods. The target of Callistephus chinensis was obtained from SwissTargetPrediction database, while the target related to diabetes was obtained from GeneCards and OMIM databases. The target was added in String database to build the protein interaction network. GO biological process enrichment analysis and KEGG pathway enrichment analysis were carried out by Metascape software, then the target-pathway network was constructed. Molecular docking was carried out in Discovery Studio 2016 Client software to verify the binding force of Callistephus chinensis flavonoid compounds with key targets. In this study, 10 potential active components were selected from the flavonoid monomer compounds of Callistephus chinensis. 1 847 biological processes (BP), 126 cell compositions (CC) and 256 molecular functions (MF) were obtained by GO enrichment analysis; a total of 194 pathways were involved in KEGG enrichment analysis of 192 cross targets. Network analysis showed that quercetin was the main active component of flavonoids in the treatment of diabetes, AKT1, TNF, VEGFA, EGFR, SRC and other related signals were in relation to the treatment of diabetes. This study showed that Callistephus chinensis flavonoid compounds play a role in the treatment of diabetes by regulating multi-target and multi-pathway. 相关文章 | 计量指标

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Exploring the mechanism of Crocus sativus and Rosa rugosa for the treatment of coronary heart disease based on network pharmacology and molecular docking Aijinxiu Ma, Zihan Hou, Ming Yang, Xu Zhao 2024 (1):  20-32.  摘要 ( 24 )   PDF(7239KB) ( 11 )   Abstract Coronary atherosclerotic heart disease (CHD) is the main type of cardiovascular disease. The efficacy of Uyghur drug compound Saffron formula in CHD has been clinically proven. However, the underlying mechanism remains unclear. In this study, researchers investigated the active ingredients and mechanism of action of Crocus sativus and Rosa rugosa in the treatment of CHD by network pharmacology and molecular docking techniques, collected target information with the help of TCMSP, GEO, GeneCards, and other databases, constructed protein-protein interaction (PPI) network diagrams by STRING database, performed GO and KEGG pathway enrichment analysis on common targets, and finally molecularly docked the active ingredients with core targets. C. sativus-R. rugosa have a variety of polyphenol compounds, a total of 12 active ingredients, including quercetin and kaempferol, were screened. The first three targets intersected with the core targets of CHD as AKT1, TNF, and IL-1B. Enrichment results of KEGG pathway showed that C. sativus-R. rugosa against CHD involved atherosclerosis pathways. The molecular docking results showed that quercetin and kaempferol were well bound to the core targets, and it was speculated that these components might be the main active ingredients for the treatment of CHD. The potential mechanism of action of C. sativus-R. rugosa for the treatment of coronary heart disease was initially revealed. 相关文章 | 计量指标

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Relationship between tea pigments and health: A bibliometric and visual analysis Xiaoya Pan, Fangyuan Wei, Mengyuan Zhao, Xiangrong Zhang 2024 (1):  33-41.  摘要 ( 27 )   PDF(3145KB) ( 18 )   Abstract: Tea pigments have significant effects on human health. However, more attention have been paid to their physiological functions. The aim of this study was to analyze the quantitative and qualitative impact of tea pigments on human health, together with their current and potential future research directions. The study searched and screened 520 publications on WOS from January 2002 to December 2022. The article collected and collated literature published in the last 20 years and analyzed it bibliometrically for years, journals, countries, authors, topics, keywords and strongest citation bursts. The findings of keywords and strongest citation bursts revealed that the most discussed research topics were anticancer, black tea polyphenol, antioxidant, activator inhibitor, in vivo, gut microbiota, and summarize the relevant literature. As a reference for future research, the literature pointed out current shortcomings and speculated future development trend of tea pigments. 相关文章 | 计量指标