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1.

Exploration of anti-cardiac ﬁbrosis active ingredients of Eucalyptus globulus Labill. fruit and their mechanism of action based on chromatography-mass spectrometry and network pharmacology

Minjie Li, Xiaoli Wang, Tianyu Cheng, Weizhuo Tang, Xiaoshu Zhang

多酚 2023, 5 (1): 1-14.

摘要（752）

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Abstract The fruit of Eucalyptus globulus Labill., also known as “Yikouzhong (YKZ)” in China, belongs to the myrtaceae family. The aim of this study was to characterize the chemical composition of YKZ extract by GC-MS combined with LC-MS/MS. A total of 34 compounds were initially identified by GC-MS and 54 compounds were identified by LC-MS/MS positive and negative total ion flow maps. The total phenols and flavonoid-like substances were quantified using an enzyme standardization method to determine the presence of phenolic substances in them. At the same time, a network pharmacology approach based on LC-MS/MS was used to construct a “drug-component-target” network for myocardial protection, and 696 potential anti-myocardial fibrosis targets were obtained. The PPI analysis identifi ed 72 core targets, and the enrichment analysis revealed that the core targets may exert anti-myocardial fibrosis effects by regulating Lipid and atherosclerosis and Proteoglycans signaling pathways. Taken together, these results suggest that YKZ anti-cardiac fibrosis may act through multiple components and targets, and this study provides a scientific basis for the functional development and application of YKZ against myocardial fibrosis.

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2.

Application and action mechanism of polyphenol delivery system

Jia Kang, Junguo Wang, Junan Zheng, Changqing Xie, Jiaqing Cao, Xiangrong Zhang

多酚 2023, 5 (1): 15-25.

摘要（742）

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Abstract Polyphenols are a class of chemical components that are benefcial to human health. Polyphenol compounds provide advanced biomedical applications due to their antioxidant and anti-infammatory activity. They can also play a role in reducing the risk of various chronic diseases. However, most polyphenols are unstable compounds with low absorption and poor bioavailability which greatly limited their applications. Therefore, the delivery of polyphenols to specifc parts of the body has become a therapeutic necessity. In this study, the research of polyphenol delivery systems such as microspheres, nanoparticles, liposomes and gels were mainly summarized. The action mechanism of polyphenols to intestinal microbiota, tumor cells, the brain, pancreas, and liver was analyzed.

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3.

The mechanism of polyphenols in perilla against hyperuricemia using network pharmacology and molecular docking

Lingling Wang, Aijinxiu Ma, Xu Zhao

多酚 2023, 5 (1): 26-34.

摘要（653）

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Abstract To investigate the possible targets and mechanisms of polyphenols in perilla in the treatment of hyperuricemia (HUA) Batman-TCM, TCMSP, PubMed, and CNKI databases were used to obtain the main components of perilla and component- related targets. HUAtargets were collected through GeneCards and OMIM online platforms. The HUAtarget and the perilla component target were crossed to obtain a common target. Protein interaction networks were constructed using the STRING database, and the compound-target-pathway network was constructed by Cytoscape software. The GO and KEGG enrichment analysis was performed using the DAVID database. Molecular docking was used to verify the results. Thirteen potential active components, 101 component targets, 901 HUA-related targets, and 36 common targets were screened out. Through network topology analysis, core targets such as TP53, TNF, CASP3, and PPARG and active components such as luteolin, β-carotene, cyanidin, catechin, and linolenic acid ethyl ester were obtained. The topology analysis of the “compound-target- pathway” network showed that the polyphenolic compounds luteolin, cyanidin, and catechin were the main active components of the perilla in the treatment of HUA. This study showed that the treatment of HUA with perilla had the characteristics of a multi-component, multi-target, and multi-signal pathway, which provided a scientifc basis for further study on the molecular mechanism of the treatment of HUAwith the potential active components of perilla.

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4.

Polyphenols extracted from Aronia melanocarpa by combined enzymatic and ultrasonication and their antioxidant potential and antimicrobial activity

Xinzhu Zhang, Ming Song, Weizhuo Xu, Wei Xu

多酚 2023, 5 (1): 35-47.

摘要（543）

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Abstract The extraction of polyphenols from Aronia melanocarpa was carried out using a combination of enzymatic and ultrasound. After single-factor and orthogonal design and experiment, the optimized polyphenol extraction conditions were 1% enzyme, 1:40 material-to-liquid ratio, 55 ℃, 60 min ultrasonication, 70% ethanol, and the fi nal extraction amount was 88.634 mg/g, which displayed a 25.15% and 34.08% improvement compared with the single ultrasonication and enzymatic extraction methods, respectively. Significant antibacterial effects of polyphenols were shown against Staphylococcus aureus, Escherichia coli and Bacillus subtilis. Further antioxidation eff ects were evaluated, and the superoxide anion radical scavenging rate, hydroxyl radical scavenging rate and DPPH free radical scavenging rate reached 45.2%, 83.5% and 85.4%, respectively. This combined enzymatic and ultrasonic extraction method exhibited the advantages of high extraction rate, saving solvent consumption and extraction time, but also provided a new method for the development and utilization of natural antimicrobial and antioxidant health products.

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5. Optimization of extraction of polyphenols from pomegranate peel by orthogonal experiment design and antioxidant activity

Hanxin Zhang, Junan Zhen, Jiajun Yin, Caihong Shi, Xiangrong Zhang

多酚 2023, 5 (2): 51-59.

摘要（71）

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The aim of this study was to investigate the extraction process and antioxidant activity of polyphenols from Yunnan Mengzi pomegranate peel. Single factor and orthogonal test were used as optimize the extract rate (ER) of polyphenols from pomegranate peel (PGP). The polyphenols antioxidant activity was evaluated by DPPH·, ·OH and total reducing ability, and compared with that of Vc. The optimum extraction conditions of polyphenols were as follows: ethanol concentration of 50%, liquid-solid ratio of 50:1, extraction temperature of 90 °C, extraction for 4 h. Under these conditions, the ER of polyphenols from GPG was 8.15%. The results showed that the scavenging eff ects of polyphenols and Vc on DPPH·, ·OH increased with increasing concentration, and the scavenging eff ect of polyphenols on DPPH· was higher than Vc in rang of 0.1-1.6 μg/mL. When the concentration is greater than 0.6 μg/mL, the scavenging eff ects of plyphenols on ·OH is higher than Vc. The total reducing ability of polyphenols from PGP improved with the increase of concentration, and when the concentration was 8 μg/mL, the total reducing ability was 114 U/mL.

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6. Exploring the mechanism of hypolipidemic effect of polyphenols in wolfberry based on network pharmacology and molecular docking

Ming Yang, Honghui Zhao, Xu Zhao

多酚 2023, 5 (2): 60-70.

摘要（62）

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To explore the mechanism of hypolipidemic action of wolfberry polyphenols by using network pharmacology and molecular docking. The active ingredients and targets of wolfberry were searched by TCMSP, and the Cytoscape 3.9.0 software was used to construct a “ wolfberry component-target” network. The Gene Cards database was used to screen the hyperlipidemic targets and intersect them with the active targets of wolfberry to construct the PPI network using the STRING platform. The gene ontology (GO) function and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis of the core targets were carried out on the Metascape platform, and molecular docking of the active ingredients to the core targets was performed using AutoDockTools software. A total of 33 active ingredients and 173 potential targets of wolfberry were screened, including 99 targets related to hyperlipidemia. The results of the analysis of 99 intersecting targets with the components of wolfberry identifi ed the core active ingredients as quercetin, glycitein and atropine. The binding of the major components of wolfberry, including the polyphenolic compounds quercetin and glycitein, as well as atropine to the key targets AKT1, IL6 and TNF may be important mechanisms for the hypolipidemic therapeutic eff ect. GO functional enrichment analysis involves biological processes, cellular components, and molecular functions. The KEGG pathway enrichment analysis mainly involves the AGE-RAGE signaling pathway, fluid shear stress, and TNF signaling pathway. Molecular docking validated the good binding activity of the targets to the active ingredients. The binding of atropine and the polyphenolic compounds quercetin and glycitein to the key targets AKT1, IL6 and TNF may be an important mechanism for the hypolipidemic therapeutic effect of wolfberry.

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7. Molecular mechanism of Solanum Nigrum Linn in alcoholic liver damage based on network pharmacology and molecular docking

Ziqi Sun, Xiaoli Wang, Xueying Wang, Nan Yang, Xiaoshu Zhang

多酚 2023, 5 (2): 71-80.

摘要（59）

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Solanum Nigrum Linn, the purpose of this study was to characterize the chemical components of the extract of Solanum Nigrum Linn by LC-MS/MS, and to identify 29 compounds by positive and negative total ion flow maps. The potential mechanism of action of Solanum Nigrum Linn in treating alcoholic liver injury was investigated by means of network pharmacology and molecular docking. A total of 288 component target genes and 1 010 disease target genes were obtained, and 98 intersection targets and 7 core targets were obtained after the intersection of the two genes. GO analysis and KEGG analysis respectively obtained 20 signaling pathways such as anti-infl ammation and anti-apoptosis. The results of molecular docking showed that the blood components could successfully dock with the target proteins of the disease such as GAPDH, IL6, SRC, EGFR and ESR1. This study provided a scientifi c basis for the development and application of Solanum Nigrum Linn.

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8. Polyphenol content and antioxidant activity in mulberry powder treated at high temperature

Jiajun Yin, Junan Zheng, Xin Li, Jiaqing Cao, Xinyao Guan, Xiangrong Zhang

多酚 2023, 5 (2): 81-87.

摘要（49）

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The aim of this study was to investigate changes of polyphenols content and the antioxidant activity of mulberry fruit powder after heating at high temperature. The mulberry fruit powder was heated by baking method at different temperature and time. The DPPH scavenging ability, the OH^•- scavenging ability and the O₂^•- scavenging ability were used to evaluate the changes in the antioxidant activity of the mulberry fruit powder after the heat treatment. The results showed that 74.87% of the polyphenols in the mulberry powder were lost after heating at 150 ℃ for 5 min, and almost all the polyphenols were lost with the increase of the heating time and temperature. The antioxidant experiment showed that the DPPH scavenging rate, OH^•- scavenging rate and O₂^•- scavenging rate of mulberry fruit powder were 68.90%, 39.15% and 14.09%, respectively after treatment at 150 ℃ for 5 min. Mulberry fruit powder still has some potential to be added to baked goods as a functional ingredient.

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9. Preparation and release of curcumin/silk fibroin/sodium alginate film

Yerong Yuan, Jun’an Zheng, Zunchao Liu, Wei Li, Jiaqing Cao, Xiangrong Zhang

多酚 2024, 6 (1): 1-10.

摘要（32）

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Abstract The aim of this study was to prepare silk fibroin/sodium alginate composite film containing curcumin by casting method. Orthogonal test was used to optimize the formulation according to the values of tensile strength and elongation at break. The release of curcumin in the optimal film was studied in order to explore its application as wound dressing. The results showed that the optimum composition of curcumin/silk fibroin/sodium alginate composite film was as follows: Silk fibroin (70 mg/mL) 2.7 g, sodium alginate (24 mg/mL) 0.84 g, span 40 (5.0 mg/mL) 0.4 g, glycerol (3.75%, V/V) 3 mL, curcumin (0.2 mg/mL) 0.016 g. The optimum film showed the tensile strength and the elongation at break was (0.628 ± 0.032) MPa and (0.794 ± 0.046) %, respectively.

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10. The mechanism of Callistephus chinensis flavonoid compounds in the treatment of diabetes using network pharmacology and molecular docking

Mingyuan Yuan, Xiaoli Wang, Ziqi Sun, Xiaoshu Zhang

多酚 2024, 6 (1): 11-19.

摘要（27）

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Abstract The purpose of this project is used for exploring the mechanism of Callistephus chinensis in the treatment of diabetes by network pharmacology and molecular docking methods. The target of Callistephus chinensis was obtained from SwissTargetPrediction database, while the target related to diabetes was obtained from GeneCards and OMIM databases. The target was added in String database to build the protein interaction network. GO biological process enrichment analysis and KEGG pathway enrichment analysis were carried out by Metascape software, then the target-pathway network was constructed. Molecular docking was carried out in Discovery Studio 2016 Client software to verify the binding force of Callistephus chinensis flavonoid compounds with key targets. In this study, 10 potential active components were selected from the flavonoid monomer compounds of Callistephus chinensis. 1 847 biological processes (BP), 126 cell compositions (CC) and 256 molecular functions (MF) were obtained by GO enrichment analysis; a total of 194 pathways were involved in KEGG enrichment analysis of 192 cross targets. Network analysis showed that quercetin was the main active component of flavonoids in the treatment of diabetes, AKT1, TNF, VEGFA, EGFR, SRC and other related signals were in relation to the treatment of diabetes. This study showed that Callistephus chinensis flavonoid compounds play a role in the treatment of diabetes by regulating multi-target and multi-pathway.

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11. Relationship between tea pigments and health: A bibliometric and visual analysis

Xiaoya Pan, Fangyuan Wei, Mengyuan Zhao, Xiangrong Zhang

多酚 2024, 6 (1): 33-41.

摘要（27）

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Abstract: Tea pigments have significant effects on human health. However, more attention have been paid to their physiological functions. The aim of this study was to analyze the quantitative and qualitative impact of tea pigments on human health, together with their current and potential future research directions. The study searched and screened 520 publications on WOS from January 2002 to December 2022. The article collected and collated literature published in the last 20 years and analyzed it bibliometrically for years, journals, countries, authors, topics, keywords and strongest citation bursts. The findings of keywords and strongest citation bursts revealed that the most discussed research topics were anticancer, black tea polyphenol, antioxidant, activator inhibitor, in vivo, gut microbiota, and summarize the relevant literature. As a reference for future research, the literature pointed out current shortcomings and speculated future development trend of tea pigments.

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12. Exploring the mechanism of Crocus sativus and Rosa rugosa for the treatment of coronary heart disease based on network pharmacology and molecular docking

Aijinxiu Ma, Zihan Hou, Ming Yang, Xu Zhao

多酚 2024, 6 (1): 20-32.

摘要（24）

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Abstract Coronary atherosclerotic heart disease (CHD) is the main type of cardiovascular disease. The efficacy of Uyghur
drug compound Saffron formula in CHD has been clinically proven. However, the underlying mechanism remains unclear.
In this study, researchers investigated the active ingredients and mechanism of action of Crocus sativus and Rosa rugosa in
the treatment of CHD by network pharmacology and molecular docking techniques, collected target information with the
help of TCMSP, GEO, GeneCards, and other databases, constructed protein-protein interaction (PPI) network diagrams by
STRING database, performed GO and KEGG pathway enrichment analysis on common targets, and finally molecularly
docked the active ingredients with core targets. C. sativus-R. rugosa have a variety of polyphenol compounds, a total of 12
active ingredients, including quercetin and kaempferol, were screened. The first three targets intersected with the core targets
of CHD as AKT1, TNF, and IL-1B. Enrichment results of KEGG pathway showed that C. sativus-R. rugosa against CHD
involved atherosclerosis pathways. The molecular docking results showed that quercetin and kaempferol were well bound to
the core targets, and it was speculated that these components might be the main active ingredients for the treatment of CHD.
The potential mechanism of action of C. sativus-R. rugosa for the treatment of coronary heart disease was initially revealed.

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The online submission system of “Journal of Polyphenols” has officially opened

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Asian Journal of Pharmaceutical Sciences

Asian Journal of Traditional Medicines

Asian Journal of Social Pharmacy