多酚杂志

本期目录

2022年, 第4卷, 第2期　刊出日期：2022-12-26 上一期   

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Alginate-chitosan conjugated nanoliposome for catechin: Preparation, characterization and stability Wenxin Wu, Jingjing Lv, Hao Wang, Shuting Zhang, Xiangrong Zhang, Baoshan Sun 2022 (2):  67-76.  摘要 ( 351 )   PDF(1843KB) ( 381 )   Abstract Catechin (CTC) is a phenolic active compound with multiple biological activities. However, CTC is relatively unstable, easily oxidized and poorly soluble in water, showing limited bioavailability, which is a challenge for its application in the pharmaceutical and food industry. The purpose of this study was to promote the controlled release of CTC in the simulated gastrointestinal (GI) tract by using biopolymer-coupled nanoliposomes (NL). The nanoliposome was characterized by multifunctional polycrystalline X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The results exhibited that the size of the nanocarrier was in the range of 87-178 nm, the encapsulation efficiency of CTC was 93.5%, and the combination of chitosan (CS) and alginate (ALG) was better than that of monopolymer. In vitro digestion studies showed that ALG-CS-NL significantly controlled the release of CTC by the diffusion, dissolution, and slow release mechanism and retained about 33%-37% of CTC under the GI condition. These results demonstrated that ALG-CS -NL could increase the stability of CTC, which may be important for the development of nutraceutical-enriched functional foods. 相关文章 | 计量指标

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Application and preliminary mechanism of dietary polyphenols in fruits against hyperuricemia Honghui Zhao, Danni Song, Xu Zhao 2022 (2):  77-86.  摘要 ( 373 )   PDF(1825KB) ( 181 )   Abstract Hyperuricemia is a metabolic condition caused by unbalanced production or excretion of serum uric acid (SUA) in the human body. Dietary polyphenols are non-nutritive compounds with prophylactic activity, mainly found in vegetables, fruits and other foods and herbs. Polyphenols have antibacterial, anti-inflammatory, antithrombotic and anticancer properties. Studies have shown that dietary polyphenols, such as phenolic acids and flavonoids have a significant effect on hyperuricemia. Unlike chemical drugs, dietary plant polyphenols have few side effects in the treatment of hyperuricemia. This review comprehensively discusses the dietary polyphenols in fruits, including phenolic acids, flavonoids, stilbene and lignans, and expounds their mechanism of action, which can provide a reference for the consumption of fruits in patients with hyperuricemia. 相关文章 | 计量指标

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Kaphta: Text mining web tool to extract information on the anticancer activity of polyphenols Ramon Gustavo Teodoro Marques da Silva, Samuel Lucas Santos Gomes, Paulo Muniz de Ávila, Gustavo José da Silva, Ana Lucia Fachin, Edilson Carlos Caritá, Mozart Marins 2022 (2):  87-100.  摘要 ( 420 )   PDF(3067KB) ( 570 )   Abstract In this paper, we describe the application of Kaphta architecture, a resource for text mining of the anticancer activity of polyphenols. The anticancer activity of these compounds against different types of cancer has been widely reported in the literature and they are one of the most promising molecules for the development of anticancer drugs. The architecture, which comprises four sequential and well-defined steps, uses a hybrid approach composed of a dictionary, rules and machine learning to identify abstracts containing sentences with associations between polyphenol, cancer and gene entities. The application of the architecture on 23 826 PubMed abstracts generated a knowledge base of indexed abstracts with 172 169 sentences containing, polyphenol-cancer and polyphenol-gene associations. A Web tool was implemented that allowed the user to search for information on 2 006 polyphenols, 240 cancers and 3 121 genes entities, and 11 750 polyphenol-cancer and 9 160 polyphenol-gene associations indexed in the knowledge base. A ranking algorithm calculates scores for each indexed abstract considering the number and type of sentences with entities and rules recognized. A test with users demonstrated that the visualization resources on the web tool contributes to the understanding of the association between polyphenols, genes and cancers, in comparison with the PubMed Tool. The Kaphta architecture and web tool permits to extract knowledge on the anticancer activity of polyphenols and can thus contribute to the exploration of these molecules in the development of anticancer therapies. 相关文章 | 计量指标

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Determination  of total flavonoids and its antioxidant activity in the exocarp of Aronia melanocarpa Longfa Li, Weizhuo Xu, Wei Xu, Ming Song 2022 (2):  101-111.  摘要 ( 392 )   PDF(1305KB) ( 211 )   Abstract As a kind of berry food rich in flavonoids, the determination method of total flavonoids content of Aronia melanocarpa is of great significance. This paper compares the applicability of NaNO2-Al (NO3)3-NaOH colorimetry and AlCl3 colorimetry to total flavonoids content of the exocarp of Aronia melanocarpa by Ultraviolet-visible Spectrophotometry. At the same time, we determined hydroxyl radical (OH·-) inhibition rate, superoxide anion radical (O2·-) inhibition rate and 1, 1-diphenyl-2-picrylhydrazyl radical free radical (DPPH·) scavenging rate of total flavonoids extracted from Aronia melanocarpa. It is found that AlCl3 colorimetry has good repeatability, precision, and accuracy. The method is suitable for the determination of total flavonoids in the exocarp of Aronia melanocarpa. Thus, by the established method the content of total flavonoids in the exocarp of Aronia melanocarpa was determined as high as (36.711 ± 0.034) mg/g. The results of antioxidant activity showed superoxide anion radical scavenging ability, hydroxyl radical scavenging ability and DPPH radical scavenging ability of the total flavonoids extract reached 45.33%, 87.87% and 98.05%, respectively, indicating that it had good antioxidant activity. 相关文章 | 计量指标