Journal Of
Polyphenols

Abstract: Abstract The aim of this study was to prepare silk fibroin/sodium alginate composite film containing curcumin by casting method. Orthogonal test was used to optimize the formulation according to the values of tensile strength and elongation at break. The release of curcumin in the optimal film was studied in order to explore its application as wound dressing. The results showed that the optimum composition of curcumin/silk fibroin/sodium alginate composite film was as follows: Silk fibroin (70 mg/mL) 2.7 g, sodium alginate (24 mg/mL) 0.84 g, span 40 (5.0 mg/mL) 0.4 g, glycerol (3.75%, V/V) 3 mL, curcumin (0.2 mg/mL) 0.016 g. The optimum film showed the tensile strength and the elongation at break was (0.628 ± 0.032) MPa and (0.794 ± 0.046) %, respectively.

Key words: curcumin, silk fibroin, sodium alginate, composite film