Journal Of
Polyphenols

Abstract: Liver fibrosis is the formation of extracellular matrix deposits due to excessive repair of chronic liver damage. Liver fibrosis is a necessary stage in the progression of cirrhosis, and timely intervention reverses the pathogenesis. Liver fibrosis is a dynamic and highly integrated molecular, cellular and organisational process. Currently, no specific drug is used to treat liver fibrosis, and liver transplantation is the main clinical treatment for cirrhosis. Chemical drugs are often designed to target individual genes or proteins, with kinds of side effects. Food polyphenols, which are available and safe, have unique advantages and great potential in the treatment with the liver fibrosis. This review summarizes the pathogenesis of liver fibrosis and provides examples of food polyphenols’ anti-liver fibrosis mechanisms that have been identified in recent studies, and provides some sights for the development of anti-liver fibrosis drugs.

Key words: food polyphenols, liver fibrosis, mechanism