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摘要： Abstract An efficient method for producing trimeric procyanidin C1
(PCC1) was developed through degradation of grape seed polymeric
procyanidins (PPCs), using epicatechin (EC) as nucleophile and
hydrochloric acid as catalyst. With the yield of PCC1 as the evaluation
index, the degradation conditions were optimized by Box-Behnken Design
(BBD) based on the results of single-factor experiments. The results
showed that the optimal conditions were reaction temperature of 40 ℃,
the ratio of EC and PPCs 2:1, acidity of 0.10 mol/L, and reaction time
of 20 min. The yield of PCC1 reached up to 17.7 mg by only one-step
degradation of 3 g PPCs. This work proposed a new method for large
preparation of PCC1 from waste grape seed polymeric procyanidins.
