多酚杂志

最多下载

一年内发表文章 | 两年内 | 三年内 | 全部 | 最近1个月下载排行 | 最近1年下载排行

当前位置： 两年内

Please wait a minute...


选择: 下载引用 EndNote Reference Manager ProCite BibTeX RefWorks 显示/隐藏图片

Select

1. Pharmacological effects and mechanisms of polyphenols in Radix Puerariae on liver protection and anti-diabetes Yerong Yuan, Zihui Wei, Zunchao Liu, Wei Li, Jiaqing Cao, Xiangrong Zhang 多酚    2022, 4 (1): 42-54.   摘要 （597）      PDF（pc） （1035KB）（665）    可视化    收藏 Abstract In recent years, the incidence of liver diseases and diabetes is increasing year by year, and the patients are younger than before. Although the clinical medicine treatment is effective, but it would produce side eff ects. Radix Puerariae is the dried root of the Pueraria lobata (Willd.) Ohwi. Puerarin is an isofl avone compound with polyphenol structure. It is one of the main bioactive components of Radix Puerariae. Studies have found that the application of puerarin offers beatifical act on liver protection, hypoglycemia, blood lipid, antioxidant, anti-osteoporosis, anti-cancer, anti-inflammatory and cardiovascular protection. Puerarin has been used in the treatment of liver disease and diabetes. In this study, the effect of puerarin on liver protection, diabetes treatment and the relationship between the two diseases were reviewed. The therapeutic mechanism and molecular targets of puerarin were explored in order to further improve the development of puerarin and increase its clinical application in protection against liver disease and diabetes. 相关文章 | 多维度评价

Select

2. Kaphta: Text mining web tool to extract information on the anticancer activity of polyphenols Ramon Gustavo Teodoro Marques da Silva, Samuel Lucas Santos Gomes, Paulo Muniz de Ávila, Gustavo José da Silva, Ana Lucia Fachin, Edilson Carlos Caritá, Mozart Marins 多酚    2022, 4 (2): 87-100.   摘要 （419）      PDF（pc） （3067KB）（558）    可视化    收藏 Abstract In this paper, we describe the application of Kaphta architecture, a resource for text mining of the anticancer activity of polyphenols. The anticancer activity of these compounds against different types of cancer has been widely reported in the literature and they are one of the most promising molecules for the development of anticancer drugs. The architecture, which comprises four sequential and well-defined steps, uses a hybrid approach composed of a dictionary, rules and machine learning to identify abstracts containing sentences with associations between polyphenol, cancer and gene entities. The application of the architecture on 23 826 PubMed abstracts generated a knowledge base of indexed abstracts with 172 169 sentences containing, polyphenol-cancer and polyphenol-gene associations. A Web tool was implemented that allowed the user to search for information on 2 006 polyphenols, 240 cancers and 3 121 genes entities, and 11 750 polyphenol-cancer and 9 160 polyphenol-gene associations indexed in the knowledge base. A ranking algorithm calculates scores for each indexed abstract considering the number and type of sentences with entities and rules recognized. A test with users demonstrated that the visualization resources on the web tool contributes to the understanding of the association between polyphenols, genes and cancers, in comparison with the PubMed Tool. The Kaphta architecture and web tool permits to extract knowledge on the anticancer activity of polyphenols and can thus contribute to the exploration of these molecules in the development of anticancer therapies. 相关文章 | 多维度评价

Select

3. Alginate-chitosan conjugated nanoliposome for catechin: Preparation, characterization and stability Wenxin Wu, Jingjing Lv, Hao Wang, Shuting Zhang, Xiangrong Zhang, Baoshan Sun 多酚    2022, 4 (2): 67-76.   摘要 （351）      PDF（pc） （1843KB）（381）    可视化    收藏 Abstract Catechin (CTC) is a phenolic active compound with multiple biological activities. However, CTC is relatively unstable, easily oxidized and poorly soluble in water, showing limited bioavailability, which is a challenge for its application in the pharmaceutical and food industry. The purpose of this study was to promote the controlled release of CTC in the simulated gastrointestinal (GI) tract by using biopolymer-coupled nanoliposomes (NL). The nanoliposome was characterized by multifunctional polycrystalline X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The results exhibited that the size of the nanocarrier was in the range of 87-178 nm, the encapsulation efficiency of CTC was 93.5%, and the combination of chitosan (CS) and alginate (ALG) was better than that of monopolymer. In vitro digestion studies showed that ALG-CS-NL significantly controlled the release of CTC by the diffusion, dissolution, and slow release mechanism and retained about 33%-37% of CTC under the GI condition. These results demonstrated that ALG-CS -NL could increase the stability of CTC, which may be important for the development of nutraceutical-enriched functional foods. 相关文章 | 多维度评价

Select

4. Exploration of anti-cardiac fibrosis active ingredients of Eucalyptus globulus Labill. fruit and their mechanism of action based on chromatography-mass spectrometry and network pharmacology Minjie Li, Xiaoli Wang, Tianyu Cheng, Weizhuo Tang, Xiaoshu Zhang 多酚    2023, 5 (1): 1-14.   摘要 （752）      PDF（pc） （3953KB）（344）    可视化    收藏 Abstract The fruit of Eucalyptus globulus Labill., also known as “Yikouzhong (YKZ)” in China, belongs to the myrtaceae family. The aim of this study was to characterize the chemical composition of YKZ extract by GC-MS combined with LC-MS/MS. A total of 34 compounds were initially identified by GC-MS and 54 compounds were identified by LC-MS/MS positive and negative total ion flow maps. The total phenols and flavonoid-like substances were quantified using an enzyme standardization method to determine the presence of phenolic substances in them. At the same time, a network pharmacology approach based on LC-MS/MS was used to construct a “drug-component-target” network for myocardial protection, and 696 potential anti-myocardial fibrosis targets were obtained. The PPI analysis identifi ed 72 core targets, and the enrichment analysis revealed that the core targets may exert anti-myocardial fibrosis effects by regulating Lipid and atherosclerosis and Proteoglycans signaling pathways. Taken together, these results suggest that YKZ anti-cardiac fibrosis may act through multiple components and targets, and this study provides a scientific basis for the functional development and application of YKZ against myocardial fibrosis. 相关文章 | 多维度评价

Select

5. Noradrenergic, glutamatergic and dopaminergic systems are implicated in antidepressant-like effect of flavonoids extracted from okra (Abelmoschus esculentus [L.] Moench.) fruit in the forced swimming test Fuyuan Li, Xiaozhuo Zhang, Qianqian Mao, Bo Wu, Ying Jia, Tingxu Yan 多酚    2022, 4 (1): 17-31.   摘要 （484）      PDF（pc） （1006KB）（318）    可视化    收藏 Abstract Okra (Abelmoschus esculentus [L.] Moench.) is one of the most frequently used herbals in East or West Africa, and its various biological activities have been widely studied. Flavonoids extracted from many plants are reported to have neurological properties, e. g antidepressant and antifatigue. However, its neurological protect in antidepressant-like effect of fl avonoids extracted from okra have not yet been demonstrated. The present study was aimed at investigating the antidepressant-like effect of the fl avonoids extracted from okra fruit (FOF) using the forced swimming test (FST) pattern and preliminary exploration its potential mechanism. We also used the open field test (OFT) to estimate the spontaneous locomotor activity. We found that oral administration (p. o.) of FOF (300 mg/kg) alone signifi cantly reduced the immobility time in the FST without changes in locomotor activity in the OPT. The experimental data indicated the antidepressant-like effect of FOF involved in noradrenergic, glutamatergic and dopaminergic systems. 相关文章 | 多维度评价

Select

6. Galangin probably ameliorates hyperuricemia by inhibiting urate acid transport 1 (URAT1): Homology modeling and mechanism exploration Aijinxiu Ma, Fuqi Wang, Xu Zhao 多酚    2022, 4 (1): 55-63.   摘要 （547）      PDF（pc） （2075KB）（295）    可视化    收藏 Abstract Urate acid transporter 1 (URAT1) is the main transporter of uric acid reabsorption, which closely related to the pathogenesis of hyperuricemia. Screening URAT1 inhibitors and studying their possible metabolic processes is a hot spot in the development of uric acid-lowering drugs. Studies have shown that many food-borne plant polyphenols have uric acid lowering activity with non-toxic side eff ects, and can be used to improve and alleviate hyperuricemia. In this study, we take galangin (GAL) as an example to explore the mechanism of plant polyphenols affecting hyperuricemia by inhibiting URAT1. Homology modeling was used to construct a three-dimensional model of URAT1 protein, and the structure was optimized. Ramachandran diagram was used to verify the rationality of model protein structure. A known URAT1 inhibitor, benzbromarone (BBR), was used to dock with URAT1 to determine the docking site and show the key amino acids. GAL and model protein were docked by molecular docking method to analyze their interaction. Meanwhile, comparing the interaction of BBR and GAL with the key amino acids of model proteins, the binding of GAL was more stable, suggesting that GAL could aff ects hyperuricemia by inhibiting URAT1. This paper aims to provide theoretical guidance for the development of new functional food ingredients for lowering uric acid. 相关文章 | 多维度评价

Select

7. Efficient semisynthetic approach for large preparation of procyanidin C1 through degradation of grape seed polymeric procyanidins Qian Li, Lina Zhang, Danyang Wang, Mengyao Zhao, Baoshan Sun, Shuting Zhang 多酚    2022, 4 (1): 32-41.   摘要 （554）      PDF（pc） （2593KB）（261）    可视化    收藏 Abstract An efficient method for producing trimeric procyanidin C1 (PCC1) was developed through degradation of grape seed polymeric procyanidins (PPCs), using epicatechin (EC) as nucleophile and hydrochloric acid as catalyst. With the yield of PCC1 as the evaluation index, the degradation conditions were optimized by Box-Behnken Design (BBD) based on the results of single-factor experiments. The results showed that the optimal conditions were reaction temperature of 40 ℃, the ratio of EC and PPCs 2:1, acidity of 0.10 mol/L, and reaction time of 20 min. The yield of PCC1 reached up to 17.7 mg by only one-step degradation of 3 g PPCs. This work proposed a new method for large preparation of PCC1 from waste grape seed polymeric procyanidins. 相关文章 | 多维度评价

Select

8. Determination  of total flavonoids and its antioxidant activity in the exocarp of Aronia melanocarpa Longfa Li, Weizhuo Xu, Wei Xu, Ming Song 多酚    2022, 4 (2): 101-111.   摘要 （392）      PDF（pc） （1305KB）（211）    可视化    收藏 Abstract As a kind of berry food rich in flavonoids, the determination method of total flavonoids content of Aronia melanocarpa is of great significance. This paper compares the applicability of NaNO2-Al (NO3)3-NaOH colorimetry and AlCl3 colorimetry to total flavonoids content of the exocarp of Aronia melanocarpa by Ultraviolet-visible Spectrophotometry. At the same time, we determined hydroxyl radical (OH·-) inhibition rate, superoxide anion radical (O2·-) inhibition rate and 1, 1-diphenyl-2-picrylhydrazyl radical free radical (DPPH·) scavenging rate of total flavonoids extracted from Aronia melanocarpa. It is found that AlCl3 colorimetry has good repeatability, precision, and accuracy. The method is suitable for the determination of total flavonoids in the exocarp of Aronia melanocarpa. Thus, by the established method the content of total flavonoids in the exocarp of Aronia melanocarpa was determined as high as (36.711 ± 0.034) mg/g. The results of antioxidant activity showed superoxide anion radical scavenging ability, hydroxyl radical scavenging ability and DPPH radical scavenging ability of the total flavonoids extract reached 45.33%, 87.87% and 98.05%, respectively, indicating that it had good antioxidant activity. 相关文章 | 多维度评价

Select

9. The mechanism of polyphenols in perilla against hyperuricemia using network pharmacology and molecular docking Lingling Wang, Aijinxiu Ma, Xu Zhao 多酚    2023, 5 (1): 26-34.   摘要 （657）      PDF（pc） （3154KB）（210）    可视化    收藏 Abstract To investigate the possible targets and mechanisms of polyphenols in perilla in the treatment of hyperuricemia (HUA) Batman-TCM, TCMSP, PubMed, and CNKI databases were used to obtain the main components of perilla and component- related targets. HUAtargets were collected through GeneCards and OMIM online platforms. The HUAtarget and the perilla component target were crossed to obtain a common target. Protein interaction networks were constructed using the STRING database, and the compound-target-pathway network was constructed by Cytoscape software. The GO and KEGG enrichment analysis was performed using the DAVID database. Molecular docking was used to verify the results. Thirteen potential active components, 101 component targets, 901 HUA-related targets, and 36 common targets were screened out. Through network topology analysis, core targets such as TP53, TNF, CASP3, and PPARG and active components such as luteolin, β-carotene, cyanidin, catechin, and linolenic acid ethyl ester were obtained. The topology analysis of the “compound-target- pathway” network showed that the polyphenolic compounds luteolin, cyanidin, and catechin were the main active components of the perilla in the treatment of HUA. This study showed that the treatment of HUA with perilla had the characteristics of a multi-component, multi-target, and multi-signal pathway, which provided a scientifc basis for further study on the molecular mechanism of the treatment of HUAwith the potential active components of perilla. 相关文章 | 多维度评价

Select

10. Application and action mechanism of polyphenol delivery system Jia Kang, Junguo Wang, Junan Zheng, Changqing Xie, Jiaqing Cao, Xiangrong Zhang 多酚    2023, 5 (1): 15-25.   摘要 （742）      PDF（pc） （2527KB）（182）    可视化    收藏 Abstract Polyphenols are a class of chemical components that are benefcial to human health. Polyphenol compounds provide advanced biomedical applications due to their antioxidant and anti-infammatory activity. They can also play a role in reducing the risk of various chronic diseases. However, most polyphenols are unstable compounds with low absorption and poor bioavailability which greatly limited their applications. Therefore, the delivery of polyphenols to specifc parts of the body has become a therapeutic necessity. In this study, the research of polyphenol delivery systems such as microspheres, nanoparticles, liposomes and gels were mainly summarized. The action mechanism of polyphenols to intestinal microbiota, tumor cells, the brain, pancreas, and liver was analyzed. 相关文章 | 多维度评价

Select

11. Application and preliminary mechanism of dietary polyphenols in fruits against hyperuricemia Honghui Zhao, Danni Song, Xu Zhao 多酚    2022, 4 (2): 77-86.   摘要 （373）      PDF（pc） （1825KB）（181）    可视化    收藏 Abstract Hyperuricemia is a metabolic condition caused by unbalanced production or excretion of serum uric acid (SUA) in the human body. Dietary polyphenols are non-nutritive compounds with prophylactic activity, mainly found in vegetables, fruits and other foods and herbs. Polyphenols have antibacterial, anti-inflammatory, antithrombotic and anticancer properties. Studies have shown that dietary polyphenols, such as phenolic acids and flavonoids have a significant effect on hyperuricemia. Unlike chemical drugs, dietary plant polyphenols have few side effects in the treatment of hyperuricemia. This review comprehensively discusses the dietary polyphenols in fruits, including phenolic acids, flavonoids, stilbene and lignans, and expounds their mechanism of action, which can provide a reference for the consumption of fruits in patients with hyperuricemia. 相关文章 | 多维度评价

Select

12. RNA-seq analysis of protective effect of epicatechin gallate on H2O2-induced oxidative injury in PC12 cells Nan Cheng, Xinxin Lin, Jiayue Xu, Kai Wang, Kaile Wang, Zhengping Liu, Parhat Kamel, Fang Wang 多酚    2022, 4 (1): 1-16.   摘要 （552）      PDF（pc） （35754KB）（100）    可视化    收藏 Abstract Epicatechin gallate (ECG) is one of the polyphenolic compounds and has attracted much attention due to its various bioactivities. In this study, the neuroprotective effect of ECG against H2O2-induced oxidative injury in PC12 cells as well as the possible mechanisms were investigated. Cell viability was determined by MTT assay. The differentially expressed genes (DEGs), GO enrichment, and KEGG enrichment were analyzed to explore the mechanism of ECG against H2O2-induced oxidative injury by using the RNA-seq method. Finally, the change in the cell cycle was analyzed by flow cytometry. H2O2 (400-1200 μ mol/L) inhibited the cell viability in a concentration-dependent manner. ECG (6-150 μmol/L) eff ectively attenuated the H2O2-induced decrease in cell viability. RNA-seq analysis showed that ECG regulated 1 058 coexpressed DEGs. GO enrichment analysis showed that the cellular component was the dominant group after ECG treatment. KEGG analysis showed that the cell cycle, fanconi anemia pathway, and homologous recombination were the important pathways for ECG in improving H2O2-induced oxidative injury and 28 coexpressed DEGs in the cell cycle pathway were summarized. Finally, cell cycle analysis also proved that ECG improved H2O2-induced cell cycle arrest in the G2/M phase. Our present study demonstrated that ECG attenuated H2O2-induced neurologic oxidative damage by multiple modulatory mechanisms at the molecular transcription level. These fi ndings provide new insights for further study of the molecular mechanism of the neuroprotection of ECG. 相关文章 | 多维度评价

Select

13. Polyphenols extracted from Aronia melanocarpa by combined enzymatic and ultrasonication and their antioxidant potential and antimicrobial activity Xinzhu Zhang, Ming Song, Weizhuo Xu, Wei Xu 多酚    2023, 5 (1): 35-47.   摘要 （545）      PDF（pc） （999KB）（81）    可视化    收藏 Abstract The extraction of polyphenols from Aronia melanocarpa was carried out using a combination of enzymatic and ultrasound. After single-factor and orthogonal design and experiment, the optimized polyphenol extraction conditions were 1% enzyme, 1:40 material-to-liquid ratio, 55 ℃, 60 min ultrasonication, 70% ethanol, and the fi nal extraction amount was 88.634 mg/g, which displayed a 25.15% and 34.08% improvement compared with the single ultrasonication and enzymatic extraction methods, respectively. Significant antibacterial effects of polyphenols were shown against Staphylococcus aureus, Escherichia coli and Bacillus subtilis. Further antioxidation eff ects were evaluated, and the superoxide anion radical scavenging rate, hydroxyl radical scavenging rate and DPPH free radical scavenging rate reached 45.2%, 83.5% and 85.4%, respectively. This combined enzymatic and ultrasonic extraction method exhibited the advantages of high extraction rate, saving solvent consumption and extraction time, but also provided a new method for the development and utilization of natural antimicrobial and antioxidant health products. 相关文章 | 多维度评价

Select

14. Exploring the mechanism of hypolipidemic effect of polyphenols in wolfberry based on network pharmacology and molecular docking Ming Yang, Honghui Zhao, Xu Zhao 多酚    2023, 5 (2): 60-70.   摘要 （64）      PDF（pc） （5201KB）（65）    可视化    收藏 To explore the mechanism of hypolipidemic action of wolfberry polyphenols by using network pharmacology and molecular docking. The active ingredients and targets of wolfberry were searched by TCMSP, and the Cytoscape 3.9.0 software was used to construct a “ wolfberry component-target” network. The Gene Cards database was used to screen the hyperlipidemic targets and intersect them with the active targets of wolfberry to construct the PPI network using the STRING platform. The gene ontology (GO) function and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis of the core targets were carried out on the Metascape platform, and molecular docking of the active ingredients to the core targets was performed using AutoDockTools software. A total of 33 active ingredients and 173 potential targets of wolfberry were screened, including 99 targets related to hyperlipidemia. The results of the analysis of 99 intersecting targets with the components of wolfberry identifi ed the core active ingredients as quercetin, glycitein and atropine. The binding of the major components of wolfberry, including the polyphenolic compounds quercetin and glycitein, as well as atropine to the key targets AKT1, IL6 and TNF may be important mechanisms for the hypolipidemic therapeutic eff ect. GO functional enrichment analysis involves biological processes, cellular components, and molecular functions. The KEGG pathway enrichment analysis mainly involves the AGE-RAGE signaling pathway, fluid shear stress, and TNF signaling pathway. Molecular docking validated the good binding activity of the targets to the active ingredients. The binding of atropine and the polyphenolic compounds quercetin and glycitein to the key targets AKT1, IL6 and TNF may be an important mechanism for the hypolipidemic therapeutic effect of wolfberry. 相关文章 | 多维度评价

Select

15. Molecular mechanism of Solanum Nigrum Linn in alcoholic liver damage based on network pharmacology and molecular docking Ziqi Sun, Xiaoli Wang, Xueying Wang, Nan Yang, Xiaoshu Zhang 多酚    2023, 5 (2): 71-80.   摘要 （62）      PDF（pc） （5441KB）（47）    可视化    收藏 Solanum Nigrum Linn, the purpose of this study was to characterize the chemical components of the extract of Solanum Nigrum Linn by LC-MS/MS, and to identify 29 compounds by positive and negative total ion flow maps. The potential mechanism of action of Solanum Nigrum Linn in treating alcoholic liver injury was investigated by means of network pharmacology and molecular docking. A total of 288 component target genes and 1 010 disease target genes were obtained, and 98 intersection targets and 7 core targets were obtained after the intersection of the two genes. GO analysis and KEGG analysis respectively obtained 20 signaling pathways such as anti-infl ammation and anti-apoptosis. The results of molecular docking showed that the blood components could successfully dock with the target proteins of the disease such as GAPDH, IL6, SRC, EGFR and ESR1. This study provided a scientifi c basis for the development and application of Solanum Nigrum Linn. 相关文章 | 多维度评价

Select

16. Optimization of extraction of polyphenols from pomegranate peel by orthogonal experiment design and antioxidant activity Hanxin Zhang, Junan Zhen, Jiajun Yin, Caihong Shi, Xiangrong Zhang 多酚    2023, 5 (2): 51-59.   摘要 （71）      PDF（pc） （1614KB）（45）    可视化    收藏 The aim of this study was to investigate the extraction process and antioxidant activity of polyphenols from Yunnan Mengzi pomegranate peel. Single factor and orthogonal test were used as optimize the extract rate (ER) of polyphenols from pomegranate peel (PGP). The polyphenols antioxidant activity was evaluated by DPPH·, ·OH and total reducing ability, and compared with that of Vc. The optimum extraction conditions of polyphenols were as follows: ethanol concentration of 50%, liquid-solid ratio of 50:1, extraction temperature of 90 °C, extraction for 4 h. Under these conditions, the ER of polyphenols from GPG was 8.15%. The results showed that the scavenging eff ects of polyphenols and Vc on DPPH·, ·OH increased with increasing concentration, and the scavenging eff ect of polyphenols on DPPH· was higher than Vc in rang of 0.1-1.6 μg/mL. When the concentration is greater than 0.6 μg/mL, the scavenging eff ects of plyphenols on ·OH is higher than Vc. The total reducing ability of polyphenols from PGP improved with the increase of concentration, and when the concentration was 8 μg/mL, the total reducing ability was 114 U/mL. 相关文章 | 多维度评价

Select

17. Polyphenol content and antioxidant activity in mulberry powder treated at high temperature Jiajun Yin, Junan Zheng, Xin Li, Jiaqing Cao, Xinyao Guan, Xiangrong Zhang 多酚    2023, 5 (2): 81-87.   摘要 （50）      PDF（pc） （3496KB）（32）    可视化    收藏 The aim of this study was to investigate changes of polyphenols content and the antioxidant activity of mulberry fruit powder after heating at high temperature. The mulberry fruit powder was heated by baking method at different temperature and time. The DPPH scavenging ability, the OH•- scavenging ability and the O2•- scavenging ability were used to evaluate the changes in the antioxidant activity of the mulberry fruit powder after the heat treatment. The results showed that 74.87% of the polyphenols in the mulberry powder were lost after heating at 150 ℃ for 5 min, and almost all the polyphenols were lost with the increase of the heating time and temperature. The antioxidant experiment showed that the DPPH scavenging rate, OH•- scavenging rate and O2•- scavenging rate of mulberry fruit powder were 68.90%, 39.15% and 14.09%, respectively after treatment at 150 ℃ for 5 min. Mulberry fruit powder still has some potential to be added to baked goods as a functional ingredient. 相关文章 | 多维度评价

Select

18. The mechanism of Callistephus chinensis flavonoid compounds in the treatment of diabetes using network pharmacology and molecular docking Mingyuan Yuan, Xiaoli Wang, Ziqi Sun, Xiaoshu Zhang 多酚    2024, 6 (1): 11-19.   摘要 （28）      PDF（pc） （4622KB）（25）    可视化    收藏 Abstract The purpose of this project is used for exploring the mechanism of Callistephus chinensis in the treatment of diabetes by network pharmacology and molecular docking methods. The target of Callistephus chinensis was obtained from SwissTargetPrediction database, while the target related to diabetes was obtained from GeneCards and OMIM databases. The target was added in String database to build the protein interaction network. GO biological process enrichment analysis and KEGG pathway enrichment analysis were carried out by Metascape software, then the target-pathway network was constructed. Molecular docking was carried out in Discovery Studio 2016 Client software to verify the binding force of Callistephus chinensis flavonoid compounds with key targets. In this study, 10 potential active components were selected from the flavonoid monomer compounds of Callistephus chinensis. 1 847 biological processes (BP), 126 cell compositions (CC) and 256 molecular functions (MF) were obtained by GO enrichment analysis; a total of 194 pathways were involved in KEGG enrichment analysis of 192 cross targets. Network analysis showed that quercetin was the main active component of flavonoids in the treatment of diabetes, AKT1, TNF, VEGFA, EGFR, SRC and other related signals were in relation to the treatment of diabetes. This study showed that Callistephus chinensis flavonoid compounds play a role in the treatment of diabetes by regulating multi-target and multi-pathway. 相关文章 | 多维度评价

Select

19. Preparation and release of curcumin/silk fibroin/sodium alginate film Yerong Yuan, Jun’an Zheng, Zunchao Liu, Wei Li, Jiaqing Cao, Xiangrong Zhang 多酚    2024, 6 (1): 1-10.   摘要 （32）      PDF（pc） （1550KB）（21）    可视化    收藏 Abstract The aim of this study was to prepare silk fibroin/sodium alginate composite film containing curcumin by casting method. Orthogonal test was used to optimize the formulation according to the values of tensile strength and elongation at break. The release of curcumin in the optimal film was studied in order to explore its application as wound dressing. The results showed that the optimum composition of curcumin/silk fibroin/sodium alginate composite film was as follows: Silk fibroin (70 mg/mL) 2.7 g, sodium alginate (24 mg/mL) 0.84 g, span 40 (5.0 mg/mL) 0.4 g, glycerol (3.75%, V/V) 3 mL, curcumin (0.2 mg/mL) 0.016 g. The optimum film showed the tensile strength and the elongation at break was (0.628 ± 0.032) MPa and (0.794 ± 0.046) %, respectively. 相关文章 | 多维度评价

Select

20. Relationship between tea pigments and health: A bibliometric and visual analysis Xiaoya Pan, Fangyuan Wei, Mengyuan Zhao, Xiangrong Zhang 多酚    2024, 6 (1): 33-41.   摘要 （28）      PDF（pc） （3145KB）（20）    可视化    收藏 Abstract: Tea pigments have significant effects on human health. However, more attention have been paid to their physiological functions. The aim of this study was to analyze the quantitative and qualitative impact of tea pigments on human health, together with their current and potential future research directions. The study searched and screened 520 publications on WOS from January 2002 to December 2022. The article collected and collated literature published in the last 20 years and analyzed it bibliometrically for years, journals, countries, authors, topics, keywords and strongest citation bursts. The findings of keywords and strongest citation bursts revealed that the most discussed research topics were anticancer, black tea polyphenol, antioxidant, activator inhibitor, in vivo, gut microbiota, and summarize the relevant literature. As a reference for future research, the literature pointed out current shortcomings and speculated future development trend of tea pigments. 相关文章 | 多维度评价

Select

21. Exploring the mechanism of Crocus sativus and Rosa rugosa for the treatment of coronary heart disease based on network pharmacology and molecular docking Aijinxiu Ma, Zihan Hou, Ming Yang, Xu Zhao 多酚    2024, 6 (1): 20-32.   摘要 （24）      PDF（pc） （7239KB）（15）    可视化    收藏 Abstract Coronary atherosclerotic heart disease (CHD) is the main type of cardiovascular disease. The efficacy of Uyghur drug compound Saffron formula in CHD has been clinically proven. However, the underlying mechanism remains unclear. In this study, researchers investigated the active ingredients and mechanism of action of Crocus sativus and Rosa rugosa in the treatment of CHD by network pharmacology and molecular docking techniques, collected target information with the help of TCMSP, GEO, GeneCards, and other databases, constructed protein-protein interaction (PPI) network diagrams by STRING database, performed GO and KEGG pathway enrichment analysis on common targets, and finally molecularly docked the active ingredients with core targets. C. sativus-R. rugosa have a variety of polyphenol compounds, a total of 12 active ingredients, including quercetin and kaempferol, were screened. The first three targets intersected with the core targets of CHD as AKT1, TNF, and IL-1B. Enrichment results of KEGG pathway showed that C. sativus-R. rugosa against CHD involved atherosclerosis pathways. The molecular docking results showed that quercetin and kaempferol were well bound to the core targets, and it was speculated that these components might be the main active ingredients for the treatment of CHD. The potential mechanism of action of C. sativus-R. rugosa for the treatment of coronary heart disease was initially revealed. 相关文章 | 多维度评价